Skip to main content

Habituelle Aborte

Habitual abortion


Habituelle Aborte (HA) betreffen etwa 1–3% aller Paare mit Kinderwunsch. Sowohl parentale Chromosomenberrationen, erworbene und vererbte Thrombophilie, Autoimmundefekte, Hormonstörungen als auch Fehlbildungen der weiblichen Genitalien sind bekannte Risikofaktoren für HA. Um Einblicke in die Pathophysiologie von Schwangerschaften zu erbringen, die durch wiederholte Fehlgeburten unterbrochen werden, fassen wir in dieser Übersichtsarbeit – gestützt auf Forschungsberichte und internationale Leitlinien – die aktuellen Erkenntnisse hinsichtlich Diagnose und Behandlung der HA zusammen.


Recurrent miscarriage (RM) affects about 1–3% of couples with the desire to have children. Parental chromosomal aberrations, malformations of the female genitalia, infectious diseases, endocrine disorders, autoimmune defects as well as acquired and inherited thrombophilia are established risk factors for RM. In this review we summarize the current concepts on diagnosis and treatment of RM, drawing on research reports and international guidelines to provide insights into the pathophysiology of terminated pregnancy due to habitual abortion.

This is a preview of subscription content, access via your institution.


  1. 1.

    Carrington B, Sacks G, Regan L (2005) Recurrent miscarriage: pathophysiology and outcome. Curr Opin Obstet Gynecol 17:591–597

    PubMed  Article  Google Scholar 

  2. 2.

    Rai R, Regan L (2006) Recurrent miscarriage. Lancet 368:601–611

    PubMed  Article  Google Scholar 

  3. 3.

    Franssen MT, Korevaar JC, Leschot HJ et al (2005) Selective chromosome analysis in couples with two or more miscarriages: case – control study. BMJ 331:137–141

    PubMed  Article  Google Scholar 

  4. 4.

    Eiben B, Bartels I, Bähr-Porsch S et al (1990) Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and ist implications for studying genetic causes of pregnancy wastage. Am J Hum Genet 47:656–663

    PubMed  CAS  Google Scholar 

  5. 5.

    Pauer HU, Von Beust G, Bartels I (1999) Zytogenetische Ursachen von Aborten. Reproduktionsmedizin 15:124–132

    Article  Google Scholar 

  6. 6.

    Abalovich M, Gutierrez S, Alcaraz G et al (2002) Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 12:63–68

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Christiansen OB, Pedersen B, Rosgaard A, Husth M (2002) A randomized, double-blind, placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarriage: evidence for a therapeutic effect in women with secondary recurrent miscarriage. Hum Reprod 17:809–816

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4:295–306

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Crowther MA, Wisloff F (2005) Evidence based treatment of the antiphospholipid syndrome II. Optimal anticoagulant therapy for thrombosis. Thromb Res 115:3–8

    PubMed  CAS  Google Scholar 

  10. 10.

    Kupferminc MJ (2003) Thrombophilia and pregnancy. Reprod Biol Endocrinol 1:111

    PubMed  Article  Google Scholar 

  11. 11.

    Rey E, Kahn SR, David M, Shrier I (2003) Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 361:901–908

    PubMed  Article  Google Scholar 

  12. 12.

    Coulam CB, Jeyendran RS, Fishel LA et al (2006) Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage. Am J Reprod Immunol 55:360–368

    PubMed  Article  CAS  Google Scholar 

  13. 13.

    Rand JH, Wu XX, Quinn AS et al (2003) Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. Am J Pathol 163:1193–2000

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Bogdanova N, Horst J, Chlystun M et al (2007) A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. Hum Mol Genet 16:573–578

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Tiscia G, Colaizzo D, Chinni E et al (2009) Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications. Thromb Haemost 102:309–313

    PubMed  CAS  Google Scholar 

  16. 16.

    Lussana F, Dentali F, Abbate R et al (2009) Screening for thrombophilia and antithrombotic prophylaxis in pregnancy: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res 124:e19–e25

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Bates SM, Greer, IA, Pabinger I et al (2008). Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edn). Chest 133:844S–886S

    PubMed  Article  CAS  Google Scholar 

Download references


Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information



Corresponding author

Correspondence to N. Bogdanova.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Preisler-Adams, S., Bogdanova, N. Habituelle Aborte. medgen 23, 271–274 (2011).

Download citation


  • Fehlgeburt
  • Habituelle Aborte
  • Thrombophilie
  • Genetische Prädisposition
  • Risikofaktoren


  • Fetal death
  • Habitual abortion
  • Thrombophilia
  • Genetic predisposition
  • Risk factors