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„Syndrom“ multiple Sklerose

Komplexe genetische Beiträge zur offenen Pathogenese mit vielgestaltiger Klinik

Multiple sclerosis syndrome

Complex genetic components of open pathogenesis with widespread clinical symptoms

Zusammenfassung

Manifestation und Verlauf der multifaktoriell bedingten Erkrankung multiple Sklerose (MS) als häufigster neuroinflammatorischer/-degenerativer Erkrankung des Nervensystems unterliegen mannigfaltigen genetischen und Umwelteinflüssen. Differenzialdiagnostik und (symptomorientierte) Therapie bedürfen neben modernen technischen Hilfsmitteln des erfahrenen Neurologen, um andere chronische entzündlich-degenerative Prozesse auszuschließen bzw. die Behandlung optimal anzupassen. Bemühungen, den komplexen genetischen MS-Beitrag aufzuklären, zeigen Teilerfolge in vertiefter Kooperation zwischen Klinik und Grundlagenforschung.

Abstract

The manifestation and disease progress of multiple sclerosis (MS), the most common multifactorial neuroinflammatory and degenerative disease, is based on manifold genetic and environmental influences. Diagnostics and symptom-oriented therapies necessitate experienced neurologists and modern technological measures in order to exclude other chronic inflammatory degenerative processes and to optimize treatment. Through devoted cooperation of clinical and basic research, efforts to elucidate the complex genetic components of MS have begun to show some success.

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Correspondence to D.A. Akkad.

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Akkad, D., Epplen, J. & Gold, R. „Syndrom“ multiple Sklerose. medgen 19, 342–345 (2007). https://doi.org/10.1007/s11825-007-0031-5

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Schlüsselwörter

  • Multiple Sklerose
  • Multifaktoriell
  • Komplexe Klinik
  • Komplexe Genetik
  • Grundlagenforschung

Keywords

  • Multiple sclerosis
  • Multifactorial
  • Complex clinics
  • Complex genetics
  • Basic research