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Chronisch-entzündliche Krankheiten

Von Krankheitsgenen zur genomischen Pathophysiologie

Chronic inflammatory bowel disease

From genes for specific illnesses to genomic pathophysiology

Zusammenfassung

Morbus Crohn und Colitis ulcerosa sind die wesentlichen Formen der chronisch entzündlichen Darmerkrankungen (CED). Die systematische Aufklärung von Suszeptibilitätsgenen für diese komplexen Krankheitsbilder hat das pathophysiologische Verständnis wesentlich verändert. Die Vervollständigung der genetischen Risikokarte wird zukünftig zu einer Neuausrichtung von Therapien führen.

Abstract

Crohn disease and ulcerative colitis are the two main forms of chronic inflammatory bowel disease (IBD). The systematic discovery of susceptibility genes for this complex disease has led to fundamental changes in our understanding of pathophysiological concepts. The construction of a genetic risk map will guide future therapeutic development.

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Correspondence to S. Schreiber.

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Die aus der eigenen Gruppe referierten Arbeiten wurden u. a. durch das 5. Rahmenprogramm der EU sowie die BMBF-Programme „Nationales Genomforschungsnetz“ und „Kompetenznetz Chronisch entzündliche Darmerkrankungen“ und die Deutsche Forschungsgemeinschaft (FOR423) unterstützt.

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Schreiber, S. Chronisch-entzündliche Krankheiten. medgen 19, 5–9 (2007). https://doi.org/10.1007/s11825-007-0006-6

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Schlüsselwörter

  • Morbus Crohn
  • Colitis ulcerosa
  • Chronisch entzündliche Darmerkrankung (CED)
  • Suszeptibilitätsgene
  • Genetische Risikokarte

Keywords

  • Crohn’s disease
  • Ulcerative colitis
  • Chronic inflammatory bowel disease (IBD)
  • Susceptibility genes
  • Genetic risk map