Skip to main content
SpringerLink
Log in

Aktuelle Entwicklungen in der Schlafforschung und Schlafmedizin – eine Einschätzung der AG „Pathophysiologie und Schlaf“

Current developments in sleep research and sleep medicine: an assessment of the “pathophysiology and sleep” taskforce

  • Übersichten
  • Published:
Somnologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pépin J‑L, Peppard PE, Sinha S, Tufik S, Valentine K, Malhotra A (2019) Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. https://doi.org/10.1016/S2213-2600(19)30198-5

    Article  PubMed  PubMed Central  Google Scholar 

  2. Yumino D, Redolfi S, Ruttanaumpawan P, Su M‑C, Smith SGEN, Mak S, Bradley TD (2010) Nocturnal rostral fluid shift A unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure. Circulation 2010(121):1598–1605. https://doi.org/10.1161/CIRCULATIONAHA.109.902452Circulation

    Article  Google Scholar 

  3. Zinchuk A, Yaggi HK (2020) Phenotypic subtypes of OSA: a challenge and opportunity for precision medicine. Chest 157(2):403–420. https://doi.org/10.1016/j.chest.2019.09.002

    Article  PubMed  Google Scholar 

  4. McEvoy RD, Antic NA, Heeley E, Yuanming L, Ou Q, Xilong Z, Mediano O, Chen R, Drager LF, Zhihong L, Guofang C, Du B, McArdle N, Mukherjee S, Tripathi M, Billot L, Li Q, Biostat M, Lorenzi-Filho G, Barbe F, Redline S, Jiguang W, Arima H, Neal B, White DP, Grunstein RR, Nanshan Z, Craig S. Anderson for the SAVE Investigators and Coordinators (2016) CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med. https://doi.org/10.1056/NEJMoa1606599

    Article  PubMed  Google Scholar 

  5. Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho M‑P, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H (2015) Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med. https://doi.org/10.1056/NEJMoa1506459

    Article  PubMed  PubMed Central  Google Scholar 

  6. Spiesshoefer J, Becker S, Tuleta I, Mohr M, Diller GP, Emdin M, Rezeda AF, Yilmaz A, Boentert M, Giannoni A (2019) Impact of simulated hyperventilation and periodic breathing on Sympatho-vagal balance and Hemodynamics in patients with and without heart failure. Respiration. https://doi.org/10.1159/000502155

    Article  PubMed  Google Scholar 

  7. Emdin M, Mirizzi G, Giannoni A, Poletti R, Iudice G, Bramanti F, Passino C (2017) Prognostic significance of central apneas throughout a 24-hour period in patients with heart failure. J Am Coll Cardiol. https://doi.org/10.1016/j.jacc.2017.07.740

    Article  PubMed  PubMed Central  Google Scholar 

  8. Gorbachevski M, Spiesshoefer J, Arzt M, Oldenburg O, Becker S, Tuleta I, Emdin M, Passino C, Sciarrone P, Boentert M, Giannoni A (2020) Adaptive servo-ventilation therapy does not favourably alter sympatho-vagal balance in sleeping patients with systolic heart failure and central apnoeas: Preliminary data. Int J Cardiol. https://doi.org/10.1016/j.ijcard.2020.03.078

    Article  PubMed  Google Scholar 

  9. Spiesshoefer J, Hegerfeld N, Gerdes MF, Klemm S, Gorbachevski M, Radke R, Tuleta I, Passino C, Xiaoyi J, Sciarrone P, Randerath W, Dreher M, Boentert M, Giannoni A (2020) Effects of central apneas on sympathovagal balance and hemodynamics at night: impact of underlying systolic heart failure. Sleep Breath. https://doi.org/10.1007/s11325-020-02144-8

    Article  PubMed  PubMed Central  Google Scholar 

  10. Spiesshoefer J, Herkenrath S, Harre K, Kahles F, Florian A, Yilmaz A, Mohr M, Naughton M, Randerath W, Emdin M, Passino C, Regmi B, Dreher M, Boentert M, Giannoni A (2021) Sleep-disordered breathing and nocturnal hypoxemia in Precapillary pulmonary hypertension: prevalence, Pathophysiological determinants, and clinical consequences. Respiration. https://doi.org/10.1159/000515602

    Article  PubMed  Google Scholar 

  11. Passino C, Sciarrone P, Vergaro G, Borrelli C, Spiesshoefer J, Gentile F, Emdin M, Giannoni A (2021) Sacubitril-valsartan treatment is associated with decrease in central apneas in patients with heart failure with reduced ejection fraction. Int J Cardiol. https://doi.org/10.1016/j.ijcard.2021.02.012

    Article  PubMed  Google Scholar 

  12. Spiesshoefer J (2019) Cheyne-Stokes respiration in heart failure: Only provocative pathophysiology will provide new insights! Int J Cardiol. https://doi.org/10.1016/j.ijcard.2019.04.094

    Article  PubMed  Google Scholar 

  13. Gentile F, Borrelli C, Sciarrone P, Buoncristiani F, Spiesshoefer J, Bramanti F, Iudice G, Vergaro G, Emdin M, Passino C, Giannoni A (2022) Central apneas are more detrimental in female than in Male patients with heart failure. J Am Heart Assoc. https://doi.org/10.1161/JAHA.121.024103

    Article  PubMed  PubMed Central  Google Scholar 

  14. Förderung der Else-Kröner Fresenius Stiftung der Arbeitsgruppe um Dr. med. Jens Spiesshoefer zur Erforschung zentraler Atemregulationsstörungen: Projektvolumen ~200.000 Euro. https://www.ekfs.de/wissenschaftliche-foerderung/aktuelle-foerderungen/pathophysiologische-grundlagen-zentraler

  15. Spiesshoefer J, Young P, Boentert M (2019) Neuromuskuläre Erkrankungen und Schlaf. Nervenheilkunde. https://doi.org/10.1055/a-0818-9117

    Article  Google Scholar 

  16. Vitacca M, Montini A, Lunetta C, Banfi P, Bertella E, De Mattia E, Lizio A, Volpato E, Lax A, Morini R, Paneroni M, ALS RESPILOM Study Group (2018) Impact of an early respiratory care programme with non-invasive ventilation adaptation in patients with amyotrophic lateral sclerosis. Eur J Neurol. https://doi.org/10.1111/ene.13547

    Article  PubMed  Google Scholar 

  17. Spiesshoefer J, Storre JH, Dreher M (2021) Non-invasive home-ventilation: Pathophysiology, initiation and follow up. Dtsch Med Wochenschr. https://doi.org/10.1055/a-1242-8710

    Article  PubMed  Google Scholar 

  18. Spiesshoefer J, Runte M, Heidbreder A, Dreher M, Young P, Brix T, Boentert M (2019) Sleep-disordered breathing and effects of non-invasive ventilation on objective sleep and nocturnal respiration in patients with myotonic dystrophy type I. Neuromuscul Disord. https://doi.org/10.1016/j.nmd.2019.02.006

    Article  PubMed  Google Scholar 

  19. Runte M, Spiesshoefer J, Heidbreder A, Dreher M, Young P, Brix T, Boentert M (2019) Sleep-related breathing disorders in facioscapulohumeral dystrophy. Sleep Breath. https://doi.org/10.1007/s11325-019-01843-1

    Article  PubMed  Google Scholar 

  20. Spiesshoefer J, Herkenrath S, Henke C, Langenbruch L, Schneppe M, Randerath W, Young P, Brix T, Boentert M (2020) Evaluation of respiratory muscle strength and diaphragm ultrasound: normative values, theoretical considerations and practical recommendations. Respiration. https://doi.org/10.1159/000506016

    Article  PubMed  Google Scholar 

  21. Spiesshoefer J, Henke C, Herkenrath S, Randerath W, Schneppe M, Young P, Brix T, Boentert M (2019) Electrophysiological properties of the human diaphragm assessed by magnetic phrenic nerve stimulation: normal values and theoretical considerations in healthy adults. J Clin Neurophysiol. https://doi.org/10.1097/WNP.0000000000000608

    Article  PubMed  Google Scholar 

  22. Spiesshoefer J, Henke C, Kabitz HJ, Brix T, Görlich D, Herkenrath S, Randerath W, Young P, Boentert M (2019) The nature of respiratory muscle strength impairment in patients with late-onset-Pompe-disease. Neuromuscul Disord. https://doi.org/10.1016/j.nmd.2019.06.011

    Article  PubMed  Google Scholar 

  23. Spiesshoefer J, Henke C, Kabitz H‑J, Akova-Oeztuerk E, Draeger B, Herkenrath S, Randerath W, Young P, Brix T, Boentert M (2019) Phrenic nerve involvement and respiratory muscle weakness in patients with Charcot Marie Tooth disease 1A. J Peripher Nerv Syst. https://doi.org/10.1111/jns.12341

    Article  PubMed  Google Scholar 

  24. Henke C, Spiesshoefer J, Kabitz H‑J, Herkenrath S, Randerath W, Brix T, Görlich D, Young P, Boentert M (2019) Characteristics of respiratory muscle involvement in myotonic dystrophy type 1. Neuromuscul Disord. https://doi.org/10.1016/j.nmd.2019.10.011

    Article  PubMed  Google Scholar 

  25. Henke C, Spiesshoefer J, Kabitz H‑J, Herkenrath S, Randerath W, Brix T, Görlich D, Young P, Boentert M (2019) Respiratory muscle weakness in facioscapulohumeral muscular dystrophy. Muscle Nerve. https://doi.org/10.1002/mus.26717

    Article  PubMed  Google Scholar 

  26. Meyer AC, Spiesshoefer J, Siebers NC, Heidbreder A, Thiedemann C, Schneider H, Braun AT, Randerath W, Young P, Dreher M, Boentert M (2020) Effects of nasal high flow on nocturnal hypercapnia, sleep, and sympathovagal balance in patients with neuromuscular disorders. Sleep Breath. https://doi.org/10.1007/s11325-020-02263-2

    Article  PubMed  PubMed Central  Google Scholar 

  27. Spiesshoefer J, Lutter R, Kabitz H‑J, Henke C, Herkenrath S, Randerath W, Young P, Dreher M, Görlich Boentert DM (2021) Respiratory Muscle Function Tests and Diaphragm Ultrasound Predict Nocturnal Hypoventilation in Slowly Progressive Myopathies. Front Neurol. https://doi.org/10.3389/fneur.2021.731865

    Article  PubMed  PubMed Central  Google Scholar 

  28. Presserklärung Universitätsklinikum Aachen zur Preisverleihung des Nachwuchswissenschaftspreises 2020 der Deutschen Gesellschaft für Muskelkranke (DGM) an Dr. med. Jens Spiesshoefer. https://www.ukaachen.de/kliniken-institute/klinik-fuer-pneumologie-und-internistische-intensivmedizin-medizinische-klinik-v/aktuelles/news/dr-spiesshoefer-erhaelt-den-juniorpreis-2022-der-deutschen-gesellschaft-fuer-muskelkranke-e-v/

  29. Überarbeitung S2 Leitlinie chronisch respiratorische Erschöpfung hin zur S3 Leitlinie. https://www.awmf.org/leitlinien/detail/anmeldung/1/ll/001-021.html. Zugegriffen: 15.07.2022

  30. Grandner MA, Hale L, Moore M, Patel NP (2010) Mortality associated with short sleep duration: The evidence, the possible mechanisms, and the future. Sleep Med Rev. https://doi.org/10.1016/j.smrv.2009.07.006

    Article  PubMed  Google Scholar 

  31. Wang C, Bangdiwala SI, Rangarajan S, Lear SA, AlHabib KF, Mohan V, Teo K, Poirier P, Tse LA, Liu Z, Rosengren A, Kumar R, Lopez-Jaramillo P, Yusoff K, Monsef N, Krishnapillai V, Ismail N, Seron P, Dans AL, Kruger L, Yeates K, Leach L, Yusuf R, Orlandini A, Wolyniec M, Bahonar A, Mohan I, Khatib R, Temizhan A, Li W, Yusuf S (2018) Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries. Eur Heart J. https://doi.org/10.1093/eurheartj/ehy695

    Article  PubMed  PubMed Central  Google Scholar 

  32. Cappuccio FP, Cooper D, Delia L, Strazzullo P, Miller MA (2011) Sleep duration predicts cardiovascular outcomes: A systematic review and meta-analysis of prospective studies. Eur Heart J. https://doi.org/10.1093/eurheartj/ehr007

    Article  PubMed  Google Scholar 

  33. Spiesshoefer J, Linz D, Skobel E, Arzt M, Stadler S, Schoebel C, Fietze I, Penzel T, Sinha A‑M, Fox H, Olaf Oldenburg On Behalf Of The German Cardiac Society Working Group On Sleep Disordered Breathing AG (2019) Sleep – the yet underappreciated player in cardiovascular diseases: A clinical review from the German Cardiac Society Working Group on Sleep Disordered Breathing. Eur J Prev Cardiolog. https://doi.org/10.1177/2047487319879526

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Pneumologie und internistische Intensivmedizin, RWTH Universitätsklinikum Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland

    Jens Spiesshoefer

  2. Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italien

    Jens Spiesshoefer

  3. Medizinische Klinik III, Pneumologie, Pneumologische Onkologie, Allergologie, Schlaf- und Beatmungsmedizin, Theresienkrankenhaus Mannheim, Mannheim, Deutschland

    Maritta Orth

Authors
  1. Jens Spiesshoefer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maritta Orth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jens Spiesshoefer.

Ethics declarations

Interessenkonflikt

J. Spiesshoefer und M. Orth geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

figure qr

QR-Code scannen & Beitrag online lesen

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Spiesshoefer, J., Orth, M. Aktuelle Entwicklungen in der Schlafforschung und Schlafmedizin – eine Einschätzung der AG „Pathophysiologie und Schlaf“. Somnologie 26, 169–173 (2022). https://doi.org/10.1007/s11818-022-00365-5

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11818-022-00365-5

Search

Navigation