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The association of sleep with inflammatory bowel disease in children and adolescents

Die Assoziation zwischen Schlaf und chronisch-entzüdlichen Darmerkrankungen bei Kindern und Jugendlichen: ein systematischer Review

Abstract

Aim

To systematically review literature investigating sleep quality in children and adolescents with inflammatory bowel disease (IBD).

Methods

Electronic databases were searched (BASE, Cochrane Database of Systematic Reviews, DIMDI, PsychArticles, PsychInfo, Psychjournals, Psychline, PSYNDEX, Pubmed, Science Direct, Web of Science, Wiley Online Library) by two researchers. Eligible studies were all that studied sleep disorders in the context of IBD in children and adolescents (6–17 years of age).

Results

Out of 40 references identified, five studies (all cross-sectional, three of them controlled) were eligible and included in this study. The publications showed that children and adolescents with IBD have significant sleep problems, adding to their impaired quality of life.

Conclusion

The published data provide evidence suggesting an impact of IBD and its severity on sleep in children and adolescents. However, with regard to the low methodological quality, the incongruity of the studies concerning outcome measure, and their focus of exploration, further studies are warranted to highlight the interrelationship.

Zusammenfassung

Ziel

Ein systematischer Review der Literatur bezüglich der Schlafqualität bei Kindern und Jugendlichen mit chronisch-entzündlichen Darmerkrankungen (CED).

Methode

Durch zwei Forscher wurden elektronische Datenbanken durchsucht (BASE, Cochrane Database of Systematic Reviews, DIMDI, PsychArticles, PsychInfo, Psychjournals, Psychline, PSYNDEX, Pubmed, Science Direct, Web of Science, Wiley Online Library). Eingeschlossen wurden alle Studien, die Schlafstörungen im Kontext mit CED bei Kindern und Jugendlichen (6–17 Jahre alt) untersuchten.

Ergebnisse

Von 40 identifizierten Referenzen wurden fünf Studien (alle Querschnittsstudien, drei davon kontrolliert) in den Review aufgenommen. Die Studien zeigen, dass Kinder und Jugendliche mit CED erhebliche Schlafprobleme aufweisen, wodurch die ohnehin schon geminderte Lebensqualität weiter beeinträchtigt wird.

Fazit

Die bisher publizierten Studien zu diesem Thema legen nahe, dass CED und dessen Schweregrad einen Einfluss auf den Schlaf bei Kindern und Jugendlichen haben. Unter Berücksichtigung der geringen methodischen Qualität der Studien, der Inkongruenz hinsichtlich der Ergebnisvariable und des Untersuchungsfokus sind weitere Studien nötig um den Zusammenhang zu verstehen.

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Correspondence to Ann-Kristin Manhart.

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Conflict of interest

A.-K. Manhart, S. Hellmann, E. Hamelmann, and A.A. Schlarb state that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Manhart, AK., Hellmann, S., Hamelmann, E. et al. The association of sleep with inflammatory bowel disease in children and adolescents. Somnologie 20, 212–218 (2016). https://doi.org/10.1007/s11818-016-0067-3

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Keywords

  • Inflammation
  • Autoimmune disease
  • Pain
  • Quality of life
  • Sleep disorders

Schlüsselwörter

  • Entzündung
  • Autoimmunerkrankung
  • Schmerz
  • Lebensqualität
  • Schlafstörungen