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Obstruktive Schlafapnoe als Risikofaktor der Arteriosklerose

Obstructive sleep apnea as a risk factor for atherosclerosis

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Zusammenfassung

Die obstruktive Schlafapnoe (OSA) ist assoziiert mit Arteriosklerose und ihren Folgeerkrankungen wie Myokardinfarkt und ischämischem zerebralem Insult. Die pathophysiologischen Interaktionen umfassen neurale, vaskuläre, mechanische, inflammatorische und metabolische Mechanismen, die durch repetitive Hypoxämien verursacht sind und zur Progression der kardiovaskulären Erkrankungen führen. Beobachtungsstudien legen für die Therapie mit CPAP („continuous positive airway pressure“) mehrere günstige Effekte auf kardiovaskuläre Erkrankungen und ihre Prognose nahe; die Bewertung dieser Daten sowie eine definitive Therapiestrategie sind jedoch durch den Mangel an prospektiven, randomisierten Daten limitiert.

Abstract

Obstructive sleep apnea (OSA) is associated with atherosclerosis and its consequences including myocardial infarction and stroke. The pathophysiological interactions comprise neural, vascular, mechanical, inflammatory, and metabolic mechanisms, which are caused by repetitive hypoxemia and contribute to cardiovascular disease progression. In mostly observational, albeit valuable studies, treatment with CPAP (continuous positive airway pressure) has been shown to exert several beneficial effects on cardiovascular disease and prognosis; however, evaluation of the data as well as a definitive therapeutic strategy is limited by lack of prospective, randomized data.

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Deutschland

    D. Skowasch & G. Nickenig

  2. Klinik Lazariterhof/Baden-Privatklinik, MEDIAN-Kliniken Bad Krozingen, Bad Krozingen, Deutschland

    G. Bönner

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  1. D. Skowasch
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  2. G. Bönner
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Correspondence to D. Skowasch.

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Skowasch, D., Bönner, G. & Nickenig, G. Obstruktive Schlafapnoe als Risikofaktor der Arteriosklerose. Somnologie 13, 215–220 (2009). https://doi.org/10.1007/s11818-009-0436-2

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