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The use of acetylation to improve the performance of hyaluronic acid-based dermal filler

  • Biotechnology
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Korean Journal of Chemical Engineering Aims and scope Submit manuscript

Abstract

Injectable dermal fillers, which are used for various plastic surgery purposes, are experiencing explosive market growth due to increasing interest in appearance management. Hyaluronic acid (HA) hydrogels have been considered an ideal material for fillers due to their high-water retention, biodegradability, and biocompatibility. However, their application is limited by shortcomings in durability and persistence caused by rapid enzymatic degradation. Therefore, in this study, we introduce acetylated hyaluronic acid-divinyl sulfone (AcHA-DVS) hydrogels for a novel approach for improving the physical properties and gel retention time of HA. The AcHA-DVS hydrogels showed significant advantages in terms of longevity and performance as dermal fillers compared to HA-DVS hydrogels. These results suggest that our new AcHA-DVS hydrogel is a promising biomaterial as an injectable filler or scaffold for tissue engineering.

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Abbreviations

AcHA-DVS:

acetylated hyaluronic acid-divinyl sulfone

HA:

hyaluronic acid

DVS:

divinyl sulfone

MTT:

3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide

Wd :

dry mass weight

Ws :

swelling mass weight

ESR:

equilibrium swelling ratio

DMSO:

dimethylsulfoxide

DMEM:

Dulbecco’s modified Eagle’s medium

FBS:

fetal bovine serum

P/S:

penicillin-streptomycin

Calcein-AM:

calcein acetoxymethyl ester

FE-SEM:

field emission scanning electron microscope

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Acknowledgements

This work was supported by Basic Science Research Program (NRF-2020R1A2C2100794, NRF-2022R1A2C1010161) of the National Research Foundation (NRF) and Korean Fund for Regenerative Medicine (KFRM) grant (22A0104L1) funded by the Korea government.

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Author notes

  1. These authors contributed equally to this work as first author

Authors and Affiliations

  1. Department of Chemical Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 54538, Korea

    So-Jung Gwak

  2. MECHABIO Group, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 54538, Korea

    So-Jung Gwak

  3. Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon, 34114, Korea

    Yu Bin Lee

  4. Research Group for Biomimetic Advanced Technology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Korea

    Eun Joo Lee & Sun-Woong Kang

  5. Department of Polymer Science and Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Korea

    Eun Joo Lee, Kyoung Hwan Park & Kang Moo Huh

  6. Human and Environmental Toxicology Program, University of Science and Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 34114, Korea

    Sun-Woong Kang

Authors
  1. So-Jung Gwak
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  2. Yu Bin Lee
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  3. Eun Joo Lee
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  4. Kyoung Hwan Park
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  5. Sun-Woong Kang
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  6. Kang Moo Huh
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Contributions

E. J. Lee analyzed the characteristics of HA hydrogels. K. H. Park performed cell culture for the cytotoxicity test of the hydrogels. S.-J. Gwak and Y. B. Lee are the major contributors to writing the manuscript. K. M. Huh and S.-W. Kang supervised the study. All authors have read and approved the final manuscript.

Corresponding authors

Correspondence to Sun-Woong Kang or Kang Moo Huh.

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Competing Interests

The authors declare that they have no conflict of interest.

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Gwak, SJ., Lee, Y.B., Lee, E.J. et al. The use of acetylation to improve the performance of hyaluronic acid-based dermal filler. Korean J. Chem. Eng. 40, 1963–1969 (2023). https://doi.org/10.1007/s11814-023-1496-x

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  • DOI: https://doi.org/10.1007/s11814-023-1496-x

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