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Utilization of functionalized silane coatings for enhanced mechanical properties of hydroxyapatite filler

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Abstract

Silane coupling agents are widely used as molecular bridges between inorganic minerals and organic materials to modify surface properties for diverse biomedical applications. In this study, we developed hydroxyapatite (HAp)-based scaffolds by fabricating the surface of HAp pellets with silane coupling agents containing methacrylate, amine, and carboxylic acid functional groups to improve their mechanical properties for use as biodegradable fillers in dental and bone regeneration applications. Surface coating with carboxylic acid-functionalized silane exhibited a substantially enhanced mechanical strength of up to 30MPa, which possibly resulted from the stable configuration of interfacial bonding via electrostatic attractive interaction in the a-planes of the HAp pellets. Furthermore, the functionalized silane-coated HAp scaffolds displayed excellent biocompatibility, which suggests that they could be utilized as bone filler composites for bone tissue engineering.

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References

  1. N. Eliaz and N. Metoki, Materials, 10, 334 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  2. R. A. Surmenev, M. A. Surmeneva and A. A. Ivanova, Acta Biomaterialia, 10, 557 (2014).

    Article  CAS  PubMed  Google Scholar 

  3. S. V. Dorozhkin, Biomaterials, 31, 1465 (2010).

    Article  CAS  PubMed  Google Scholar 

  4. P. P. Patel, C. Buckley, B. L. Taylor, C. C. Sahyoun, S. D. Patel, A. J. Mont, L. Mai, S. Patel and J. W. Freeman, J. Biomed. Mater. Res. Part A, 107, 732 (2019).

    Article  CAS  Google Scholar 

  5. J. Jeong, J. H. Kim, J. H. Shim, N. S. Hwang and C. Y. Heo, Biomater. Res., 23, 4 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Y. Song, K. I. Joo and J. H. Seo, Biotechnol. Bioprocess Eng., 26, 201 (2021).

    Article  CAS  Google Scholar 

  7. K. Akhtar, C. Pervez, N. Zubair and H. Khalid, J. Mater. Sci.: Mater. Med., 32, 129 (2021).

    CAS  PubMed  Google Scholar 

  8. C. Santos, Z. B. Luklinska, R. L. Clarke and K. W. M. Davy, J. Mater. Sci.: Mater. Med., 12, 565 (2001).

    CAS  PubMed  Google Scholar 

  9. J. Venkatesan and S. Anil, Biotechnol. Bioprocess Eng., 26, 312 (2021).

    Article  CAS  Google Scholar 

  10. D. Puppi, F. Chiellini, A. M. Piras and E. Chiellini, Prog. Polym. Sci., 35, 403 (2010).

    Article  CAS  Google Scholar 

  11. K. Rezwan, Q. Z. Chen, J. J. Blaker and A. R. Boccaccini, Biomaterials, 27, 3413 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. Z. Wang, S. Wang, Y. Marois, R. Guidoin and Z. Zhang, Biomaterials, 26, 7387 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. E.-j. Cheon, S.-H. Kim, D.-K. Lee, Y.-K. Jo, M.-R. Ki, C.-J. Park, H.-S. Jang, J.-S. Ahn, S.-P. Pack and S.-H. Jun, Biotechnol. Bioprocess Eng., 26, 923 (2021).

    Article  CAS  Google Scholar 

  14. R. A. Sousa, R. L. Reis, A. M. Cunha and M. J. Bevis, J. Mater. Sci. Mater. Med., 14, 475 (2003).

    Article  CAS  PubMed  Google Scholar 

  15. Z. Fang and Q. Feng, Mater. Sci. Eng. C, 35, 190 (2014).

    Article  CAS  Google Scholar 

  16. O. G. Cisneros-Pineda, W. Herrera Kao, M. I. Loría-Bastarrachea, Y. Veranes-Pantoja, J. V. Cauich-Rodríguez and J. M. Cervantes-Uc, Mater. Sci. Eng. C, 40, 157 (2014).

    Article  CAS  Google Scholar 

  17. F. Liu, B. Sun, X. Jiang, S. S. Aldeyab, Q. Zhang and M. Zhu, Dent. Mater., 30, 1358 (2014).

    Article  CAS  PubMed  Google Scholar 

  18. Y. Xie, C. A. S. Hill, Z. Xiao, H. Militz and C. Mai, Compos. Part A: Appl. Sci. Manuf., 41, 806 (2010).

    Article  Google Scholar 

  19. S. C. Chowdhury, R. Prosser, T. W. Sirk, R. M. Elder and J. W. Gillespie, Appl. Surf. Sci., 542, 148738 (2021).

    Article  CAS  Google Scholar 

  20. C. Shuai, C. Shuai, P. Feng, Y. Yang, Y. Xu, T. Qin, S. Yang, C. Gao and S. Peng, Molecules, 22, 511 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  21. F. Ghorbani, M. Pourhaghgouy, T. Mohammadi-hafshehjani and A. Zamanian, Silicon, 12, 3015 (2020).

    Article  CAS  Google Scholar 

  22. A. Nikbakht, C. Dehghanian and R. Parichehr, RSC Adv., 11, 26127 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Y. J. Chuah, S. Kuddannaya, M. H. A. Lee, Y. Zhang and Y. Kang, Biomater. Sci., 3, 383 (2015).

    Article  CAS  PubMed  Google Scholar 

  24. S. Somasundaram, J. Biomed. Mater. Res. B Appl. Biomater., 106, 2901 (2018).

    Article  CAS  PubMed  Google Scholar 

  25. R. Astala and M. J. Stott, Phy. Rev. B, 78, 075427 (2008).

    Article  Google Scholar 

  26. H. Oonishi, Biomaterials, 12, 171 (1991).

    Article  CAS  PubMed  Google Scholar 

  27. W. Suchanek and M. Yoshimura, J. Mater. Res., 13, 94 (1998).

    Article  CAS  Google Scholar 

  28. I. S. Harding, N. Rashid and K. A. Hing, Biomaterials, 26, 6818 (2005).

    Article  CAS  PubMed  Google Scholar 

  29. Z. Zhuang, T. J. Fujimi, M. Nakamura, T. Konishi, H. Yoshimura and M. Aizawa, Acta Biomater, 9, 6732 (2013).

    Article  CAS  PubMed  Google Scholar 

  30. Y. In, U. Amornkitbamrung, M.-H. Hong and H. Shin, ACS Omega, 5, 27204 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by the 2019 Yeungnam University Research Grant.

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Correspondence to Jeong Hyun Seo or Kye Il Joo.

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Ji, E., Song, Y.H., Seo, J.H. et al. Utilization of functionalized silane coatings for enhanced mechanical properties of hydroxyapatite filler. Korean J. Chem. Eng. 40, 1709–1714 (2023). https://doi.org/10.1007/s11814-023-1396-0

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  • DOI: https://doi.org/10.1007/s11814-023-1396-0

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