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Ultrasonic cavitation bubble- and gas bubble-assisted fractional precipitation for the purification of (+)-dihydromyricetin

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Abstract

This study presents the ultrasonic cavitation bubble- and gas bubble-assisted fractional precipitation that dramatically improves the precipitation efficiency in existing precipitation method for purifying (+)-dihydromyricetin. Compared to the conventional method, the time required for precipitation was reduced by 40 times. The particle size was reduced by 4.0–7.4 times and 3.7–4.4 times for cavitation bubbles and gas bubbles, respectively, and the diffusion coefficient was increased by 5.1–9.2 times (cavitation bubble) and 3.7–4.4 times (gas bubble). Meanwhile, the precipitation rate constant was increased by 11.0–65.0 times and 17.0–24.6 times and the activation energy was decreased by −5,543∼−9,655 J/mol and −6,546∼−7,404 J/mol, which resulted in an improved precipitation rate. The results of the thermodynamic analysis showed that the precipitation was exothermic and non-spontaneous.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Government of Korea (MSIT) (Grant Number: 2021R1A2C1003186).

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Authors and Affiliations

  1. Center for Future Sustainable Technology, Department of Chemical Engineering, Kongju National University, Cheonan, 31080, Korea

    Jieun Hong & Jin-Hyun Kim

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  1. Jieun Hong
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  2. Jin-Hyun Kim
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Correspondence to Jin-Hyun Kim.

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Hong, J., Kim, JH. Ultrasonic cavitation bubble- and gas bubble-assisted fractional precipitation for the purification of (+)-dihydromyricetin. Korean J. Chem. Eng. 39, 3067–3073 (2022). https://doi.org/10.1007/s11814-022-1202-4

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  • DOI: https://doi.org/10.1007/s11814-022-1202-4

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