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Solvo-hydrothermal synthesis of calcium phosphate nanostructures from calcium inositol hexakisphosphate precursor in water-ethanol mixed solutions

  • Materials (Organic, Inorganic, Electronic, Thin Films)
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Abstract

We report the synthesis and characterization of crystalline calcium phosphate (CaP) nanostructures from calcium inositol hexakisphosphate (CaIP6) precursor in water-ethanol mixed solutions. We show how these CaPs can be prepared by a solvo-hydrothermal reaction and determined their compositions and structures using a battery of material characterization techniques. Our results show that only the hydroxyapatite (HAP) and dicalcium phosphate anhydrous (DCPA) phases of CaP were present in the nanostructures produced in water-ethanol mixtures, and that HAP/DCPA ratio of the rod- and plate-shaped CaP nanostructures produced were affected by the amount of ethanol present in these mixtures. The described method can be used to improve morphological control of CaP-based biomate-rials and has potential use in bone regenerative medicine.

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Acknowledgements

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Korea (NRF-2015R1D1A1 A01059580 and NRF-2019R1F1A1060060), by the Nano-Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2009–0082580), and by the Basic Core TechTechnology Development Program for the Oceans and the Polar Regions of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2015M1A5A1037054).

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Authors and Affiliations

  1. School of Chemical and Biomolecular Engineering, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, 46241, Korea

    Ji-Hoon Han & Sungwook Chung

  2. Department of Biotechnology and Bioinformatics, Korea University, 2511 Sejong-ro, Sejong, 30019, Korea

    Seung Pil Pack

Authors
  1. Ji-Hoon Han
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  2. Seung Pil Pack
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  3. Sungwook Chung
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Correspondence to Sungwook Chung.

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Solvo-hydrothermal synthesis of calcium phosphate nanostructures from calcium inositol hexakisphosphate precursor in water-ethanol mixed solutions

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Han, JH., Pack, S.P. & Chung, S. Solvo-hydrothermal synthesis of calcium phosphate nanostructures from calcium inositol hexakisphosphate precursor in water-ethanol mixed solutions. Korean J. Chem. Eng. 37, 891–897 (2020). https://doi.org/10.1007/s11814-020-0496-3

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  • DOI: https://doi.org/10.1007/s11814-020-0496-3

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