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Controlled drug release in silicone adhesive utilizing particulate additives

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Abstract

Polydimethylsiloxane (PDMS) based adhesives were prepared by cross-linking tetraethoxyorthosilicate (TEOS) while controlling stoichiometry with PDMS, acid catalyst, and water. Particulate additives, alginate and bentonite, were added during the cross-linking process. Cationic drug lidocaine was incorporated into the adhesive with or without additive, and the time-dependent drug release profile was evaluated in phosphate buffered saline and ethanol, respectively. According to kinetic fitting to power function and parabolic diffusion, both solvent and additive type influenced drug release. In particular, particulate additives were found to suppress or facilitate drug release in water or ethanol, respectively.

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Authors and Affiliations

  1. Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwondo, 26493, Korea

    Ji Eun Lee, Gyeong-Hyeon Gwak, Cheol Hyun Kim, Myong Euy Lee & Jae-Min Oh

  2. University of College, Yonsei University, Incheon, 21983, Korea

    Hyeon Mo Cho

Authors
  1. Ji Eun Lee
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  2. Gyeong-Hyeon Gwak
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  3. Hyeon Mo Cho
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  4. Cheol Hyun Kim
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  5. Myong Euy Lee
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  6. Jae-Min Oh
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Correspondence to Jae-Min Oh.

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These authors contributed equally to this work.

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Lee, J.E., Gwak, GH., Cho, H.M. et al. Controlled drug release in silicone adhesive utilizing particulate additives. Korean J. Chem. Eng. 34, 1600–1603 (2017). https://doi.org/10.1007/s11814-017-0069-2

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  • DOI: https://doi.org/10.1007/s11814-017-0069-2

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