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Hypolipidemic and antioxidant effects on hypercholesterolemic rats of polysaccharide from Salicornia bigelovii seed

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Abstract

The hypolipidemic and antioxidant effects of dietary supplementation with polysaccharide isolated from Salicornia bigelovii seed (SBS) were evaluated in hypercholesterolemic rats. Following administration of SBS polysaccharide at 200mg/kg BW/day (HPS group), total cholesterol (TC), and low density lipoprotein cholesterol (LDLC) levels were 32.45% and 58.09% lower than those in negative controls (NC) group, respectively. However, in the case of high density lipoprotein cholesterol (HDLC), it was 36.37% higher than that of NC group. The arteriosclerosis and cardiac risk indices were 64.23% and 50.53% lower than in the NC group. However, the HTR (HDLC/TC) value was higher 2.05-fold than that of the NC group. Hydroxy-3-methylglutaryl CoA reductase activity in HPS group was 55.1% lower than that of the NC group. Activities of alanine transferase, aspartate aminotransferase, and alkaline phosphatase in HPS group were 29.71%, 26.49%, and 32.24%, lower than that of the NC group. SOD, CAT, and GSH-Px activities in HPS group were 31.05%, 49.29%, and 54.62% higher than that of the NC group. These results indicate that SBS polysaccharide has both hypolipidemic and antioxidant effects and shows potential for ameliorating hypercholesterolemia.

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Authors and Affiliations

  1. Department of Urology, School of Medicine, Chosun University, Gwangju, 61452, Korea

    Dong-Hoon Lim

  2. Biotechnology Laboratory, B-K Company Ltd., Jeonbuk, 54008, Korea

    Dubok Choi

  3. Department of Biochemical Polymer Science & Engineering, Chosun University, Gwangju, 61452, Korea

    Sun-Mi Kim, YuLan Piao & Hoon Cho

  4. Biochem Lab., Shinchon E&C R&D, Gwangju, 61165, Korea

    On-You Choi

  5. Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University Graduate School, Gwangju, 61186, Korea

    Geum-Sook Lim

  6. Biosystem Course, Division of Applied Sciences, Muroran Institute of Technology, 27-1 Mizumoto, Muroran, 050-8585, Japan

    Young-Cheol Chang

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  1. Dong-Hoon Lim
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Correspondence to Hoon Cho.

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Lim, DH., Choi, D., Kim, SM. et al. Hypolipidemic and antioxidant effects on hypercholesterolemic rats of polysaccharide from Salicornia bigelovii seed. Korean J. Chem. Eng. 34, 787–796 (2017). https://doi.org/10.1007/s11814-016-0335-8

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  • DOI: https://doi.org/10.1007/s11814-016-0335-8

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