Skip to main content

Ceramide-based nanostructured lipid carriers for transdermal delivery of isoliquiritigenin: Development, physicochemical characterization, and in vitro skin permeation studies

Korean Journal of Chemical Engineering volume 34, pages 400–406 (2017)Cite this article

Abstract

An optimized, ceramide-based, nanostructured lipid carrier (NLC) formulation was developed for isoliquiritigenin (ILTG), and its potential as a transdermal delivery system was evaluated. ILTG-loaded NLCs were prepared by blending solid (ceramide, cholesterol) and liquid lipids (caprylic/capric triglyceride) in various proportions using a hot homogenization and ultrasonication method. The physicochemical characteristics were investigated by DLS, ZP, EE%, TEM, DSC and XRD analyses and in vitro skin permeation studies. The results showed that the particle size of the formulation was 150.19–251.69 nm with a ZP>−20mV. The EE% was 56.45–89.97%. The NLC structure was influenced by lipid ratio, and increasing the caprylic/capric triglyceride ratio caused a less ordered structure, as confirmed by DSC. The XRD analysis indicated that ILTG was not in the crystalline state in all formulations. The skin permeation study showed that the ILTG-NLCs promoted ILTG permeation. In conclusion, ceramide-based NLCs could be a promising vehicle for the ILTG transdermal delivery of ILTG.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. P. W. Wertz and B. Bergh, Chem. Phys. Lipids, 91, 85 (1988).

    Article  Google Scholar 

  2. S. Grayson and P. M. Elias, J. Invest. Dermatol., 78, 128 (1982).

    Article  CAS  Google Scholar 

  3. A. D. Nardo, P. Wertz, A. Giannetti and S. Seidenari, Acta. Derm. Venereol. Suppl. (Stockh), 78, 27 (1998).

    Article  Google Scholar 

  4. S. Motta, M. Monti, S. Sesana, L. Mellesi, R. Ghidoni and R. Caputo, Arch. Dermatol., 130, 452 (1994).

    Article  CAS  Google Scholar 

  5. K. Perisho, P. W. Wertz, K. C. Madison, M. E. Stewart and D. T. Downing, J. Invest. Dermatol., 90, 350 (1988).

    Article  CAS  Google Scholar 

  6. W. Abraham and D. T. Downing, Pharm. Res., 9, 1415 (1992).

    Article  CAS  Google Scholar 

  7. S. N. Park, M. H. Lee, S. J. Kim and E. R. Yu, Biochem. Biophys. Res. Commun., 435, 361 (2013).

    Article  CAS  Google Scholar 

  8. D. H. Kim, W. R. Park, J. H. Kim, E. C. Cho, E. J. An, J. W. Kim and S. G. Oh, Colloids Surf., B., 94, 236 (2012).

    Article  CAS  Google Scholar 

  9. X. Wu and R. H. Guy, J. Drug. Deliv. Sci. Technol., 19, 371 (2009).

    Article  Google Scholar 

  10. Y. R. Neupane, M. Srivastava, N. Ahmad, N. Kumar and A. Bhatnagar, Int. J. Pharm., 477, 601 (2014).

    Article  CAS  Google Scholar 

  11. W. S. Choi, H. I. Cho, H. Y. Lee, S. H. Lee and Y. W. Choi, J. Pharm. Invest., 40, 373 (2010).

    Article  CAS  Google Scholar 

  12. J. Pardeike, A. Hommoss and R. H. Muller, Int. J. Pharm., 366, 170 (2009).

    Article  CAS  Google Scholar 

  13. R. H. Muller, M. Radtke and S. A. Wissing, Int. J. Pharm., 242, 121 (2002).

    Article  CAS  Google Scholar 

  14. A. Beloqui, M. A. Solinis, A. Rodriguez-Gascon, A. J. Almeida and V. Preat, Nanomedicine, 12, 143 (2016).

    CAS  Google Scholar 

  15. X. Zhao, W. Mei, M. Gong, W. Zuo, H. Bai and H. Dai, Molecules., 169, 775 (2011).

    Google Scholar 

  16. X. Zhang, E. D. Yeung, J. Wang, E. E. Panzhinskiy, C. Tong, W. Li and J. Li, Clin. Exp. Pharmacol. Physiol., 37, 841 (2010).

    CAS  Google Scholar 

  17. O. Nerya, J. Vaya, R. Musa, S. Izrael, R. Ben-Arie and S. Tamir, J. Agric. Food Chem., 51, 1201 (2003).

    Article  CAS  Google Scholar 

  18. S. C. Kim, S. H. Byun, C. H. Yang, C. Y. Kim, J. W. Kim and S. G. Kim, Toxicology, 197, 239 (2004).

    Article  CAS  Google Scholar 

  19. X. Y. Zhang, H. Qiao, J. M. Ni, Y. B. Shi and Y. Qiang, Eur. J. Pharm. Sci., 49, 411 (2013).

    Article  CAS  Google Scholar 

  20. S. J. Kim, S. S. Kwon, S. H. Jeon, E. R. Yu and S. N. Park, Int. J. Cosmet. Sci., 36, 553 (2014).

    Article  CAS  Google Scholar 

  21. S. H. Jeon, C. Y. Yoo and S. N. Park, Colloids Surfaces B: Biointerface., 129, 7 (2015).

    Article  CAS  Google Scholar 

  22. S. S. Kwon, S. Y. Kim, B. J. Kong, K. J. Kim, G. Y. Noh, N. R. Im, J. W. Lim, J. H. Ha, J. Kim and S. N. Park, Int. J. Pharm., 483, 26 (2015).

    Article  CAS  Google Scholar 

  23. S. S. Kwon, B. J. Kong and S. N. Park, Eur. J. Pharm. Biopharm., 92, 146 (2015).

    Article  CAS  Google Scholar 

  24. Y. M. Jeong, J. H. Ha and S. N. Park, J. Ind. Eng. Chem., 35, 54 (2016).

    Article  CAS  Google Scholar 

  25. V. Teeranachaideekul, P. Boonme, E. B. Souto, R. H. Müller and V. B. Junyaprasert, J. Control. Release., 128, 134 (2008).

    Article  CAS  Google Scholar 

  26. K. Jores, W. Mehnert, M. Drechsler, H. Bunjes, C. Johann and K. Mäder, J. Control. Release., 95 217 (2004).

    Article  CAS  Google Scholar 

  27. J. Y. Fang, C. L. Fang, C. H. Liu and Y. H. Su, Eur. J. Pharm. Biopharm., 70, 633 (2008).

    Article  CAS  Google Scholar 

  28. R. H. Müller, C. Jacobs and O. Kayser, Adv. Drug Deliv. Rev., 47, 3 (2001).

    Article  Google Scholar 

  29. L. R. Rodrigues, J. Colloid Interface Sci., 449, 304 (2015).

    Article  CAS  Google Scholar 

  30. N. S. Ranpise, S. S. Korabu and V. N. Ghodake, Colloids Surf., B: Biointerfaces., 116, 81 (2014).

    Article  CAS  Google Scholar 

  31. Y. C. Kuo and H. H. Chen, Int. J. Pharm., 365, 206 (2009).

    CAS  Google Scholar 

  32. P. K. Gaur, S. Mishra, A. Verma and N. Verma, J. Exp. Nanosci., 11, 38 (2016).

    Article  CAS  Google Scholar 

  33. R. Shah, D. Eldridge, E. Palombo and I. Harding, SpringerInternational Publishing (2015).

    Google Scholar 

  34. A. Kovacevic, S. Savic, G. Vuleta, R. H. Müller and C. M. Keck, Int. J. Pharm., 406, 163 (2011).

    Article  CAS  Google Scholar 

  35. S. B. Han, S. S. Kwon, Y. M. Jeong, E. R. Yu and S. N. Park, Int. J. Cosmet. Sci., 36, 588 (2014).

    Article  CAS  Google Scholar 

  36. B. Li, B. Liu, J. Li, H. Xiao, J. Wang and G. Liang, Int. J. M. Sci., 16, 17999 (2015).

    Article  CAS  Google Scholar 

  37. Y. R. Neupane, M. Srivastava, N. Ahmad, N. Kumar, A. Bhatnagar and K. Kohli, Int. J. Pharm., 477, 601 (2014).

    Article  CAS  Google Scholar 

  38. R. N. Shamma and M. H. Aburahma, Int. J. Nanomedicine., 9, 5449 (2014).

    Article  CAS  Google Scholar 

  39. M. Pradhan, D. Singh and M. R. Singh, Chem. Phys. Lipids, 186, 9 (2015).

    Article  CAS  Google Scholar 

  40. H. Chen, Y. Wang, Y. Zhai, G. Zhai, Z. Wang and J. Liu, Colloids Surf., A: Physicochem. Eng. Asp., 465, 130 (2015).

    Article  CAS  Google Scholar 

  41. E. B. Souto, S. A. Wissing, C. M. Barbosa and R. H. Müller, Int. J. Pharm., 278, 71 (2004).

    Article  CAS  Google Scholar 

  42. Y. Zhai and G. Zhai, J. Control. Release., 193, 90 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cosmetic R&D Center, Department of Fine Chemistry, Cosmetic Industry Coupled Collaboration Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul, 01811, Korea

    Geun Young Noh, Ji Young Suh & Soo Nam Park

Authors
  1. Geun Young Noh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ji Young Suh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Soo Nam Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Soo Nam Park.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Noh, G.Y., Suh, J.Y. & Park, S.N. Ceramide-based nanostructured lipid carriers for transdermal delivery of isoliquiritigenin: Development, physicochemical characterization, and in vitro skin permeation studies. Korean J. Chem. Eng. 34, 400–406 (2017). https://doi.org/10.1007/s11814-016-0267-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11814-016-0267-3

Keywords

  • Nanostructured Lipid Carrier
  • Transdermal Delivery System
  • Ceramide
  • Isoliquiritigenin
  • MEL