Korean Journal of Chemical Engineering

, Volume 33, Issue 8, pp 2253–2267 | Cite as

Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems

  • Rakhi Singh
  • Hyune-Jea Lee
  • Ajay Kumar Singh
  • Dong-Pyo Kim
Invited Review Paper


The development and enlargement of toxic and hazardous chemicals are severely limited by health and safety concerns. We summarize studies on fully integrated micro-chemical systems and total processes to reduce accidental exposure to various regents that are toxic, explosive, or carcinogenic, which significantly improved the safety of work involving risky compounds. This review covers the leak-free continuous-flow processes of hazardous chemicals in fully integrated microfluidic systems, specially denoted as micro-total envelope systems (μ-TESs), that are conducting a serial process of the generation of hazardous reagents, in-situ purification and separation, subsequent reaction, and product isolation with improved efficiencies. These attempts suggest safe and efficient tools and processes of useful but hazardous chemicals for researchers and manufacturing workers in the field of pharmaceutic discovery, natural products, biology as well as materials synthesis.


Toxic Chemicals Total Process System Micro-total Envelopment System Separator Extraction Unit Tube in Tube System Dual Channel Microreactor Silicon Nanowire Reactor Diaze Compound Azide Carbon Monoxide Ozone Chloro Methyl Methyl Ether 


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Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2016

Authors and Affiliations

  • Rakhi Singh
    • 1
  • Hyune-Jea Lee
    • 1
  • Ajay Kumar Singh
    • 1
  • Dong-Pyo Kim
    • 1
  1. 1.Center of Applied Microfluidic Chemistry, Department of Chemical EngineeringPOSTECH (Pohang University of Science and Technology)PohangKorea

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