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The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates

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Abstract

The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.

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Authors and Affiliations

  1. Physical and Colloidal Chemistry Department, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956, Bucharest, Romania

    Mihaela Violeta Ghica, Lăcrămioara Popa & Cristina Dinu-Pîrvu

  2. Collagen Department, INCDTP, Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215, Bucharest, Romania

    Mădălina Georgiana Albu & Luminița Albu

  3. Department of Field Crops, Faculty of Agriculture, Mustafa Kemal University, 31030, Hatay, Turkey

    Durmuș Alpaslan Kaya

  4. Institute of Natural and Applied Sciences, Mustafa Kemal University, 31034, Hatay, Turkey

    Șevket Öztürk

  5. Victor Babeș University of Medicine and Pharmacy of Timisoara, 2 Piața Eftimie Murgu Str., 300041, Timișoara, Romania

    Laura-Cristina Rusu

  6. Politehnica University of Bucharest, 1 Polizu Str., 011061, Bucharest, Romania

    Ciprian Chelaru & Aurelia Meghea

  7. Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroilor Sanitari Blvd., 050513, Bucharest, Romania

    Cornelia Nitipir

Authors
  1. Mihaela Violeta Ghica
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  2. Mădălina Georgiana Albu
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  3. Durmuș Alpaslan Kaya
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  4. Lăcrămioara Popa
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  5. Șevket Öztürk
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  6. Laura-Cristina Rusu
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  7. Cristina Dinu-Pîrvu
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  8. Ciprian Chelaru
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  9. Luminița Albu
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  10. Aurelia Meghea
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  11. Cornelia Nitipir
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Corresponding authors

Correspondence to Mădălina Georgiana Albu or Laura-Cristina Rusu.

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Ghica, M.V., Albu, M.G., Kaya, D.A. et al. The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates. Korean J. Chem. Eng. 33, 1325–1330 (2016). https://doi.org/10.1007/s11814-015-0284-7

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  • DOI: https://doi.org/10.1007/s11814-015-0284-7

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