Abstract
Porcine amniotic fluid was investigated for use as a functional cosmetic ingredient. From safety tests by MTT (5-diphenyltetrazolium bromide) assay, cell viability was above 90% for 50–1,000 μg/mL concentration and porcine amniotic fluid was safe for cosmetic ingredient. From stability tests, cream containing 1% porcine amniotic fluid maintained constant physical properties for color, pH and viscosity during 28 days, and porcine amniotic fluid was stable for a cosmetic agent. Efficacy tests were done for antiwrinkle (elastase inhibition and collagenase synthesis inhibition), whitening (tyrosinase inhibition and DOPA (3,4-Dihydroxy-L-phenyl-alanine) oxidation inhibition) and antioxidation. At 500 μg/mL concentration, elastase inhibition of porcine placenta amniotic fluid was 33%, whereas that of adenosine as reference was 14%. However, porcine amniotic fluid showed relatively insignificant effect on collagenase synthesis inhibition, whitening and antioxidation activity. From this study, porcine amniotic fluid showed potential for a future antiwrinkle cosmetic agent.
Similar content being viewed by others
References
Korea Food and Drug Administration, http://www.kfda.go.kr/index.html (2009).
Cosmetics Industry Analysis Report 2009, KHIDI, Seoul (2009).
P. Elsner and H. I. Mailbach, Cosmeceuticals and active cosmetics, 2nd Ed., Taylor & Francis, New York (2005).
B. C. Ha, Cosmeceuticals, Shin Kwang Publishing, Seoul (2005).
KDA Textbook Editiong Board, Dermatology, 5th Ed., Ryo Mook-Gak, Seoul (2008).
G. Vielhaber, G. Schmaus, K. Jacobs, H. Franke, S. Lange, M. Hermann, H. Joppe and O. Koch, IFSCC, 9, 227 (2006).
S. H. Park, B.Y. Lee, C. S. Han, J.G. Kim, K. T. Kim, K. H. Kim and Y. H. Kim, J. Soc. Cosmet. Scientists Korea, 33, 101 (2007).
R. Pillai, M. Redmond and J. Roding, IFSCC, 8, 17 (2005).
J. C. Park, Herbal functional food, Hyoilbooks, Seoul (2007).
Y.-M. Zheng, H.-Y. Zhao, X.-E. Zhao, F.-S. Quan, S. Hua, X.-Y. He, J. Liu, X.-N. He and H. Lin, Reproduction, 137, 793 (2009).
B.Y. Kim, T. Kim, W.Y. Kang, B. Hyun, H.Y. Cheon and D. Kim, Korean Chem. Eng. Res., 48, 327 (2010).
G.Y. Ozqenel, B. Samil and M. Ozcan, J. Hand Surgery, 26, 332 (2001).
T. Mosmann, J. Immun. Method, 65, 55 (1983).
N. Erdemogu, B. Sener and S. Ide, J. Mol. Struct., 559, 227 (2001).
A. Yagi, T. Kanbara and N. Morinobu, Plantamedica, 3981, 517 (1986).
Y. Fujita, I. Hehara, Y. Morimoto, M. Nakashima, T. Hatano and T. Okuda, YakugakuZasshi, 108, 129 (1988).
T. Kim, Master’s Thesis, Inje University, Gimhae, Korea (2011).
H. J. Kim, T. Kim, W.Y. Kang, B. Hyun, H.Y. Cheon, B.Y. Kim and D. Kim, Korean Chem. Eng. Res., 48, 413 (2010).
K. H. Lee and S. N. Park, J. Soc. Cosmet. Scientists Korea, 34, 25 (2008).
M. J. Kim, K. R. Lim, T. K. Jung and K.-S. Yoon, J. Soc. Cosmet. Scientists Korea, 33, 33 (2007).
J.Y. Kim, H. J. Yang, K. H. Lee, S.M. Jeon, Y. J. Ahn, B. R. Won and S. N. Park, J. Soc. Cosmet. Scientists Korea, 33, 165 (2007).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kim, T., Kim, S., Kang, W. et al. Porcine amniotic fluid as possible antiwrinkle cosmetic agent. Korean J. Chem. Eng. 28, 1839–1843 (2011). https://doi.org/10.1007/s11814-011-0047-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11814-011-0047-z