Abstract
To develop a novel skin depigmenting agent from natural sources, the inhibition of melanogenesis by Chinese plants, N. glandulifrea, was evaluated. The methanol extract of this plant showed significantly down-regulated melanin synthesis in a dose-dependent manner at a non-toxic concentration in cultured B16F10 mouse melanoma cells. This extract was further fractionated by using solvent-solvent partition and silica open column chromatography to identify the active components. From GC-MS data, oleic acid methyl ester was found as one of the depigmenting agents. In conclusion, we suggest that this fraction may be a safe and effective depigmentation agent.
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References
P. A. Riley, Pigment Cell Res., 16, 548 (2003).
B. Halioua, M.G. Beumont and F. Lune, Int. J. Dermatology, 39, 801 (2000).
L. Petit and G. E. Piérard, Int. J. Cosmetic Sci., 25, 169 (2003).
S. C. Taylor, Skin Pharm. Appl. Skin Phys. 12, 139 (1999).
V. Zawa and S. T. Mhaskar, J. Cosmet Dermatol, 3, 234 (2004).
S. Briganti, E. Camera and M. Picardo, Pigment Cell Res., 16, 101 (2003).
F. Solano, S. Briganti, M. Picardo and G. Ghanem, Pigment Cell Res., 19, 550 (2006).
W. Zhu and J. Gao, J. Investig. Dermatol. Symp. Proc., 13, 20 (2008).
K. H. Wang, R. D. Lin, F. L. Hsu, Y.H. Huang, H. C. Chang, C.Y. Huang and M. H. Lee, J. Ethnopharmacol., 106, 353 (2006).
H. I. Lee, B. S. Yoo, M. A. Yoo and S.Y. Byun, Korean J. Chem. Eng., 24, 655 (2007).
Y.M. Liu, J. S. Yang and Q. H. Liu, Chem. Pharm. Bull., 52, 454 (2004).
Z. Tian, Y. M. Liu, S. B. Chen, J. S. Yang, P.G. Xiao, L. Wang and E. Wu, Molecular, 11, 693 (2206).
D. T. M. Nguyen, D. H. Nguyen, H. L. Lyun, H. B. Lee, J. H. Shin and E. K. Kim, J. Microbiol. Biotechnol., 17, 1585 (2007).
J. S. Roh, J.Y. Han, J. H. Kim and J. K. Hwang, Biol. Pharm. Bull., 27, 1976 (2004).
H. Ando, Z. M. Wen, H. Y. Kim, J. C. Valencia, G. E. Costin, H. Watabe, K. I. Yasumoto, Y. Niki, H. Kondoh, M. Ichihashi and V. J. Hearing, Biochem. J., 290, 375 (2006).
H. Ando, A. Ryu, A. Hashimoto, M. Oka and M. Ichihashi, Arch. Dermatol. Res., 290, 375 (1998).
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Nguyen, D.H., Lee, JE. & Kim, EK. Identification of depigmenting components from Nigella glandulifera Freyn. Korean J. Chem. Eng. 28, 1070–1073 (2011). https://doi.org/10.1007/s11814-010-0457-3
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DOI: https://doi.org/10.1007/s11814-010-0457-3