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Simulated moving-bed for separation of mandelic acid racemic mixtures

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Abstract

Two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Consequently, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture. Simulated moving bed (SMB) is a chromatographic process that operates continuously without losing the enantiomeric purity of outlet streams from SMB. The present work describes the enantioseparation of mandelic acid in a labscale SMB unit. Chiral stationary phase was made by packing Kromasil TBB (O,O′-bis(4-tert-buylbenzoyl) -N,N′-diallyl-L-tartar diamid) gel into empty columns. The outlet streams were sampled and analyzed by an analytical HPLC. Analysis indicated that purity values range from 82% to 94% according to the change of extract stream flow rate.

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Authors and Affiliations

  1. Department of Chemical Engineering, Chungnam National University, Daejeon, 305-764, Korea

    Eun Lee, Moon Bae Park & In Ho Kim

  2. Department of Chemical Engineering, Dong-A University, Busan, 604-714, Korea

    Jong Min Kim

  3. School of Applied Chemistry, Kyung Hee University, Yongin, 446-701, Korea

    Woo Sik Kim

Authors
  1. Eun Lee
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  2. Moon Bae Park
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  3. Jong Min Kim
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  4. Woo Sik Kim
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  5. In Ho Kim
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Corresponding author

Correspondence to In Ho Kim.

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Lee, E., Park, M.B., Kim, J.M. et al. Simulated moving-bed for separation of mandelic acid racemic mixtures. Korean J. Chem. Eng. 27, 231–234 (2010). https://doi.org/10.1007/s11814-009-0339-8

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  • DOI: https://doi.org/10.1007/s11814-009-0339-8

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