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Preparation and characterization of PVA/PVP/glycerin/antibacterial agent hydrogels using γ-irradiation followed by freeze-thawing

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Abstract

Hydrogels for wound dressings from a mixture of poly(vinyl alcohol) (PVA), poly(N-vinylpyrrolidone) (PVP), glycerin and an antibacterial agent were obtained by a γ-irradiation combined with freeze-thawing. The physical properties such as the gelation and swelling degree of the hydrogels were examined. When the PVP/PVA ratio was 6: 4 (wt%) and prepared by combined irradiation and freeze-thawing, it showed an excellent swelling capacity (>1,200%). The antibacterial effect of the hydrogels containing the antibacterial agents was observed to be effective as the concentration of antibacterial agents increased. The results demonstrated that hydrogel in a proper blending ratio could be used as a wound dressing that can accelerate wound healing with an antibacterial effect.

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Authors and Affiliations

  1. Radiation Research Center for Industry & Environment, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, 1266 Sinjeong-dong, Jeongeup-si, Jeonbuk, 580-185, Korea

    Young-Chang Nho, Youn-Mook Lim & Hui-Jeong Gwon

  2. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science Technology, Daejeon, 305-701, Korea

    Hui-Jeong Gwon

  3. Department of Industrial Chemistry, Chungnam National University, Daejeon, 305-764, Korea

    Eun-Kyung Choi

Authors
  1. Young-Chang Nho
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  2. Youn-Mook Lim
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  3. Hui-Jeong Gwon
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  4. Eun-Kyung Choi
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Correspondence to Young-Chang Nho.

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Nho, YC., Lim, YM., Gwon, HJ. et al. Preparation and characterization of PVA/PVP/glycerin/antibacterial agent hydrogels using γ-irradiation followed by freeze-thawing. Korean J. Chem. Eng. 26, 1675–1678 (2009). https://doi.org/10.1007/s11814-009-0231-6

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  • DOI: https://doi.org/10.1007/s11814-009-0231-6

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