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CMC and dynamic properties of poly(VA-b-St) copolymer micelles for drug delivery

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Abstract

The polymeric micelles from amphiphilic block copolymer poly(vinyl alcohol-b-styrene) (poly(VA-b-St)) with different syndiotacticity of poly(vinyl alcohol) (PVA) block were prepared by dialysis against water. Critical micelle concentration (CMC) and dynamic properties of poly(VA-b-St) copolymeric micelles were investigated by fluorescence techniques. From the fluorescence emission spectrum measurements using pyrene as a fluorescence probe, the observed CMC value was in the range of 0.125–4.47 mg/L. The CMC value increased with decreasing the weight ratio of PS to PVA block and with increasing the syndiotacticity of PVA block. The rate of pyrene release was very slow for block copolymers containing PVA block with higher syndiotacticity, which indicates that their micelles have increased kinetic stability.

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References

  1. F. J. Baltá Calleja and Z. Roslaniec, Block copolymers, Marcel Dekker, Inc. New York (2000).

    Google Scholar 

  2. P. Alexandridis and B. Lindman, Amphiphilic block copolymers — self assembly and applications, Elsevier Science B. V., New York (2000).

    Google Scholar 

  3. R. Gref, Y. Minamitake, M. T. Peracchia, V. Trubetskoy, V. Torchilin and R. Langer, Science, 263, 1600 (1994).

    Article  CAS  Google Scholar 

  4. A.V. Kabanov, V. P. Chekhonin, V.Y. Alakhov, E.V. Batrakova, A. S. Lebedev, N. S. Melik-Nubarov, S.A. Arzhakov, A.V. Levashov, G.V. Morozov, E. S. Severin and V.A. Kabanov, FEBS Lett., 258, 343 (1989).

    Article  CAS  Google Scholar 

  5. M. Yokoyama, M. Miyauchi, N. Yamada, T. Okano, Y. Sakurai, K. Kataoka and S. Inoue, J. Controlled Release, 11, 269 (1990).

    Article  CAS  Google Scholar 

  6. P. N. Hurter and T. A. Hatton, Langmuir, 8, 1291 (1992).

    Article  CAS  Google Scholar 

  7. I. Piirma, Polymeric surfactants, Marcel Dekker, New York (1992).

    Google Scholar 

  8. J. L. Mura and G. Riess, Polym. Adv. Technol., 6, 497 (1995).

    Article  CAS  Google Scholar 

  9. R. Nagarajan, Current Opinion in Colloid Interface Sci., 1, 391 (1996).

    Article  CAS  Google Scholar 

  10. R. Xu, M.A. Winnik, F. R. Hallett, G. Riess and M.D. Croucher, Macromolecules, 24, 87(1991).

    Article  CAS  Google Scholar 

  11. M. Wilhelm, C. L. Zhao, Y. C. Wang, R. L. Xu, M. A. Winnik, J. L. Mura, G. Riess and M. D. Croucher, Macromolecules, 24, 1033 (1991).

    Article  CAS  Google Scholar 

  12. K. Yu and A. Eisenberg, Macromolecules, 29, 6359 (1996).

    Article  CAS  Google Scholar 

  13. R. L. Xu, M.A. Winnik, G. Riess, B. Chu and M.D. Croucher, Macromolecules, 25, 644 (1992).

    Article  CAS  Google Scholar 

  14. F. Caldérara, Z. Hruska, G. Hurtrez, J. Lerch, T. Nugay and G. Riess, Macromolecules, 27, 1210 (1994).

    Article  Google Scholar 

  15. S. E. Dunn, A. Brindley, S. S. Davis, M. C. Davies and L. Illum, Pharm. Res., 11, 1016 (1994).

    Article  CAS  Google Scholar 

  16. G. J. Brown, R.W. Richards and R.K. Heenan, Polymer, 42, 7663 (2001).

    Article  CAS  Google Scholar 

  17. X. Huang and J. Huang, Colloid & Polym. Sci., 277(2–3), 291 (1999).

    Article  CAS  Google Scholar 

  18. A. Rõsler, G.W. M. Vandermeulen and H. A. Klok, Advanced Drug Delivery Reviews, 53, 95 (2001).

    Article  Google Scholar 

  19. R. Xu, M.A. Winnik, F. R. Hallett, G. Riess and M.D. Croucher, Macromolecules, 24, 87 (1991).

    Article  CAS  Google Scholar 

  20. G.H. Li and C.G. Cho, Colloid & Polymer Science, 283, 946 (2005).

    Article  CAS  Google Scholar 

  21. G. H. Li and C. G. Cho, Macromol. Res., 10(6), 339 (2002).

    CAS  Google Scholar 

  22. G. S. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai and K. Kataoka, Langmuir, 9, 945 (1993).

    Article  CAS  Google Scholar 

  23. A.V. Kabanov, I. R. Nazarova, I.V. Astafieva, E.V. Batrakova, V.Y. Alakhov, A.A. Yaroslavov and V.A. Kabanov, Macromolecules, 28, 2303 (1995).

    Article  CAS  Google Scholar 

  24. K. Kalyanasundaram and J. K. Thomas, J. Am. Chem. Soc., 99, 2039 (1977).

    Article  CAS  Google Scholar 

  25. T. Cao, P. Munk, C. Ramireddy, Z. Tuzar and S. E. Webber, Macromolecules, 24, 6300 (1991).

    Article  CAS  Google Scholar 

  26. C.A. Finch (Ed), Polyvinyl alcohol — developments, Chapter 9, John Wiley & Sons Ltd., England (1992).

    Google Scholar 

  27. K. Kankokai, PVA no Sekai, Chapter 2, Kyoto (1992).

  28. Y. Nagara, T. Nakano, Y. Okamoto, Y. Gotoh and M. Nagura, Polymer, 42, 9679 (2001).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Chemistry & Chemical Engineering, Guangxi University, No. 100 Daxue Road, Nanning, Guangxi, 530004, P.R. China

    Guang-Hua Li

  2. Department of Fiber & Polymer Engineering, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul, 133-791, Korea

    Chang-Gi Cho

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  1. Guang-Hua Li
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  2. Chang-Gi Cho
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Correspondence to Guang-Hua Li.

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Li, GH., Cho, CG. CMC and dynamic properties of poly(VA-b-St) copolymer micelles for drug delivery. Korean J. Chem. Eng. 25, 1444–1447 (2008). https://doi.org/10.1007/s11814-008-0237-5

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  • DOI: https://doi.org/10.1007/s11814-008-0237-5

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