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Clinical effects of treatment for lung cancer with double points cryoablation through percutaneous puncture guided by computed tomography

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Clinical Oncology and Cancer Research

Abstract

Objective

To investigate the clinical effects of the application of double points cryoablation through percutaneous puncture for advanced lung cancer patients.

Methods

Forty-one patients diagnosed with stage III–IV pulmonary carcinoma were selected for the study. The patients were found to have from 1 to 3 foci of carcinoma, and in each case the disease was limited to one lung. The study patients were divided randomly into 3 groups. There were 16 cases receiving routine chemotherapy and radiotherapy in group I, 13 cases treated with cryoablation at a single point in group II, and 12 cases treated with cryoablation at 2 points simultaneously in group III. The patients in the 2 cryoablation groups also received the same treatment as the patients did in group I. The clinical effects were evaluated within 6 months after treatment, and the survival rate was followed-up for 3 years.

Results

The clinical effects were improved significantly after treatment in group II and in group III compared with those in group I (P < 0.05), including an enhanced regressive rate of 21%, postponed tumor progression of 50.58% and a clinical benefit rate of 92%. The effective rate of regression in group III was higher than that in group II, 43.59% (P < 0.05), and the 3-year survival rate was 37.25%. Significant differences in side effects were not found between the 2 cryoablation groups.

Conclusion

Cryosurgery ablation at 2 points, simultaneously, and directed at 1 foci might improve the effects of treatment and the prognosis of lung cancer patients, when used in combination with routine treatment.

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References

  1. Mori K, Kobayashi H, Kamiyama Y, et al. A phase II trial of weekly chemotherapy with paclitaxel plus gemcitabine as a first-line treatment in advanced non-small-cell lung cancer. Cancer Chemother Pharmacol 2009; 64: 73–78.

    Article  CAS  PubMed  Google Scholar 

  2. Fox J, Ford E, Redmond K, et al. Quantification of Tumor Volume Changes During Radiotherapy for Non-Small-Cell Lung Cancer. Int J Radiat Oncol Biol Phys 2009; 74: 341–348.

    PubMed  Google Scholar 

  3. Dehing-Oberije C, Yu S, De Ruysscher D, et al. Development and External Validation of Prognostic Model for 2-Year Survival of Non-Small-Cell Lung Cancer Patients Treated With Chemoradiotherapy. Int J Radiat Oncol Biol Phys 2009; 74: 355–362.

    PubMed  Google Scholar 

  4. Siberman AW. Surgical debulking of tumor. Surg Gynecol Obstet 1982; 155: 577–582.

    Google Scholar 

  5. Deygas N, Froudarakis M, Ozenne G, et al. Cryotherapy in early superficial bronchogenic carcinoma. Chest 2001; 120: 26–31.

    Article  CAS  PubMed  Google Scholar 

  6. Asimakopoulos G, Beeson J, Evans J, et al. Cryosurgery for malignant endobronchial tumors: analysis of outcome. Chest 2005; 127: 2007–2014.

    Article  PubMed  Google Scholar 

  7. Johansson Bengt W. Increasing interest in cold therapy. Lakartidningen 2002; 99: 402–403.

    CAS  PubMed  Google Scholar 

  8. Ghafar MA, Johnson CW, De LaTaille A, et al. Salvage cryotherapy using an argon based system for locally recurrent prostate cancer after radiation therapy: the Columbia experience. J Urol 2001; 166: 1333–1337.

    Article  CAS  PubMed  Google Scholar 

  9. Folkman J, Browder T, Palmblad J. Angiogenesis research: guideline for translation to clinical application. Thromb Haemost 2001; 86: 23–33.

    CAS  PubMed  Google Scholar 

  10. Van Laethem JL. Adjuvant treatment for colorectal cancer. Acta Gastroenterol Belg 2001; 64: 263–267.

    PubMed  Google Scholar 

  11. Sturm JW, Keese MA, Bonninghoff RG, et al. Locally ablative therapies of hepatocellular carcinoma. Onkologie 2001; 24(5 Suppl): 35s–45s.

    Article  Google Scholar 

  12. Okuma T, Matsuoka T, Hamamoto S, et al. Percutaneous computed tomography-guided radiofrequency ablation of lung tumors complicated with idiopathic interstitial pneumonia. Ann Thorac Surg 2009; 87: 948–950.

    Article  PubMed  Google Scholar 

  13. Padda S, Kothary N, Donington J, et al. Complications of ablative therapies in lung cancer. Clin Lung Cancer 2008; 9: 122–126.

    Article  PubMed  Google Scholar 

  14. Maiwand MO, Evans JM, Beeson JE. The application of cryosurgery in the treatment of lung cancer. Cryobiology 2004; 48: 55–61.

    Article  CAS  PubMed  Google Scholar 

  15. Andersen S, Donnem T, Al-Saad S, et al. Angiogenic markers show high prognostic impact on survival in marginally operable non-small cell lung cancer patients treated with adjuvant radiotherapy. J Thorac Oncol 2009; 4: 463–471.

    PubMed  Google Scholar 

  16. Sano I, Hara S, Matsumoto K, et al. Clinical analysis of resected pulmonary pleomorphic carcinoma. Kyobu Geka 2009; 62: 187–191.

    CAS  PubMed  Google Scholar 

  17. Goudar RK, Vlahovic G. Hypoxia, angiogenesis, and lung cancer. Curr Oncol Rep 2008; 10: 277–282.

    Article  CAS  PubMed  Google Scholar 

  18. Lind JS, Herder GJ, Smit EF. New therapies for the treatment of advanced non-small cell lung cancer: inhibitors of the epidermal growth factor receptor and angiogenesis. Ned Tijdschr Geneeskd 2008; 152: 928–932.

    CAS  PubMed  Google Scholar 

  19. Romaneehsen B, Anders M, Röhrl B, et al. Cryotherapy of malignant tumors: studies with MRI in an animal experiment and comparison with morphological changes. Rofo 2001; 173: 632–638.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Oncology, Zhongda Hospital, Southeastern University, Nanjing, 210009, Jiangsu Province, China

    Zao Jiang & Xiaoyi Gu

  2. Department of Intervention Radiology, Zhongda Hospital, Southeastern University, Nanjing, 210009, Jiangsu Province, China

    Gaojun Teng, Wen Fang & Guozhao Li

Authors
  1. Zao Jiang
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  2. Gaojun Teng
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  3. Wen Fang
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  4. Xiaoyi Gu
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  5. Guozhao Li
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Correspondence to Zao Jiang.

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Jiang, Z., Teng, G., Fang, W. et al. Clinical effects of treatment for lung cancer with double points cryoablation through percutaneous puncture guided by computed tomography. Clin. Oncol. Cancer Res. 6, 322–327 (2009). https://doi.org/10.1007/s11805-009-0322-5

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  • DOI: https://doi.org/10.1007/s11805-009-0322-5

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