Abstract
Objective
To investigate the short-term and long-term therapeutic efficacy of preoperative intra-arterial infusion chemoembolization on stage IB2-IIB uterine cervix cancer (UCC).
Methods
A total of 143 patients with Stage IB2-IIB UCC were divided into a clinical trial group and a control group. The patients in the clinical trial group (n = 86) were treated with a combined therapy, i.e., preoperative intra-arterial infusion chemo-embolization, surgical therapy and postoperative radiotherapy, and those in the control group (n = 57) were given surgical therapy and post-operative radiotherapy. The adverse effects, changes in local lesion and pathological examinations of the cancer, and the state during the surgery were observed after the intra-arterial infusion chemo-embolization. The survival rate and recurrence rate between the two groups were compared.
Results
The total effective rate of the intra-arterial infusion chemo-embolization on Stage IB2-IIB UCC was 93.02%. The treatment could reduce tumor size, bring about retro-conversions of the clinical stage of the tumors and pathological grade of the cancer cells, and decrease the quantity of intra-operative blood loss as well as the operating time. It could significantly improve the 5-year survival rate (P< 0.05), and reduce the 2 and 5-year tumor recurrence rates (P < 0.05). Moreover, its side effects were little.
Conclusion
Preoperative intra-arterial infusion chemo-embolization can create conditions for radical operation, lower the postoperative recurrence rate, and improve the prognosis in the patients with UCC. It is an effective therapy in treating UCC.
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Li, H., Liu, F., Zhou, G. et al. Analysis of the curative effect of preoperative intra-arterial infusion chemoembolization on stage IB2-IIB uterine cervix cancer. Chin. J. Clin. Oncol. 5, 443–447 (2008). https://doi.org/10.1007/s11805-008-0443-2
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DOI: https://doi.org/10.1007/s11805-008-0443-2