Abstract
Oleoylchitosans (O-chitosans) with different degrees of substitution (DS) were synthesized by reacting chitosan with oleoyl chloride. The chemical structures of the products were characterized by 1H NMR and FT-IR. These results suggested the formation of an amide linkage between the amino groups of chitosan and the carboxyl groups of oleic acid. The viscosity of O-chitosan sharply increased with the increase of concentration, whereas that of unmodified chitosan rose only slightly. This increase became larger as the DS increased. All of the O-chitosans could reduce surface tension slightly. The critical aggregation concentration (CAC) of O-chitosans with DS 5%, 11%, and 27% were 79.43 mgL−1, 31.6 mgL−1, and 10 mgL−1, respectively. Nanoparticles were prepared using an O/W emulsification method. The mean diameters of the polymeric amphiphilic nanoparticles of O-chitosans with DS 5% and 11% were around 327.4 nm and 275.3 nm, respectively.
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Li, Y., Chen, X., Sun, G. et al. The aggregation behavior and formation of nanoparticles of oleoylchitosan in dilute aqueous solution. J. Ocean Univ. China 7, 199–204 (2008). https://doi.org/10.1007/s11802-008-0199-6
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DOI: https://doi.org/10.1007/s11802-008-0199-6