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Antibody-modified integrated microfluidic terahertz biosensor for detection of breast cancer biomarkers

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Abstract

Breast cancer is the most common malignant tumor in women, which seriously threatens the physical and mental health of women worldwide. The existing detection methods have problems, such as large sample consumption, time-consuming sample preparation, expensive equipment, and low sensitivity. In order to solve these problems, this paper proposes a method for quickly detecting breast cancer using surface-functionalized terahertz metamaterial biosensors. The use of PIK3CA-modified sensors enhances the detection sensitivity and specificity of exosomes. Based on the red shift of the sensor absorption peak caused by exosomes, breast cancer patients can be distinguished from healthy controls. This study demonstrates that exosome detection is effective for the repeatable and non-invasive diagnosis of breast cancer patients. The terahertz metamaterial biosensor designed in this paper has high specificity, repeatability, and sensitivity, and has great potential for application in the development of modern diagnostic instruments.

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Authors and Affiliations

  1. School of Intelligent Engineering, Shaoguan University, Shaoguan, 512005, China

    Jianjun Liu

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  1. Jianjun Liu
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Correspondence to Jianjun Liu.

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The authors declare no conflict of interest.

Additional information

This work has been supported by the Natural Science Foundation of Guangdong Province (No.2022A1515011409), the Youth Project of National Natural Science Foundation of China (Nos.52105268 and 62001200), the Science and Technology Program of Shaoguan (Nos.2019sn056, 2019sn066 and 200811094530811), the Key Project of Shaoguan University (Nos.SZ2017KJ08 and SZ2020KJ02), and the Natural Science Foundation of Fujian Province (No.2020J01817).

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Liu, J. Antibody-modified integrated microfluidic terahertz biosensor for detection of breast cancer biomarkers. Optoelectron. Lett. 20, 249–256 (2024). https://doi.org/10.1007/s11801-024-3109-2

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  • DOI: https://doi.org/10.1007/s11801-024-3109-2

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