Skip to main content
Log in

Biodegradation of trace pharmaceutical substances in wastewater by a membrane bioreactor

  • Research Article
  • Published:
Frontiers of Environmental Science & Engineering in China Aims and scope Submit manuscript

Abstract

The biodegradation of selected pharmaceutical micropollutants, including two pharmaceuticals with argued biodegradation, was studied by a lab-scale membrane bioreactor. The reaction kinetics and affecting factors were also investigated in this paper. Clofibric acid (CA) with contradictive biodegradation reported was degraded almost completely at different hydraulic retention times (HRTs) after adaptation to microorganisms. The biodegradation of CA was disturbed at low pH operation, while the activity of microorganisms recovered again after pH adjustment to neutral condition. Ibuprofen (IBP) degraded under neutral and acidic conditions. Removals of IBP and CA were zero-order and first-order reactions under high and low initial concentrations, respectively. Carbamazepine and diclofenac were not degraded regardless of HRTs and pH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Gómez M J, Martínez Bueno M J, Lacorte S, Fernández-Alba A R, Agüera A. Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere, 2007, 66(6): 993–1002

    Article  Google Scholar 

  2. Nakada N, Tanishima T, Shinohara H, Kiri K, Takada H. Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Research, 2006, 40(17): 3297–3303

    Article  CAS  Google Scholar 

  3. Heberer T. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicology Letters, 2002, 131(1–2): 5–17

    Article  CAS  Google Scholar 

  4. Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele R D. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part I histological alterations and bioaccumulation in rainbow trout. Aquatic Toxicology, 2004, 68(2): 141–150

    Article  CAS  Google Scholar 

  5. Jobling S, Nolan M, Tyler C R, Brighty G, Sumpter J P. Widespread sexual disruption in wild fish. Environmental Science & Technology, 1998, 32(17): 2498–2506

    Article  CAS  Google Scholar 

  6. Daughton C G, Ternes T A. Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environmental Health Perspective, 1999, 107(6): 907–944

    Article  CAS  Google Scholar 

  7. Urase T, Kagawa C, Kikuta T. Factors affecting removal of pharmaceutical substances and estrogens in membrane separation bioreactors. Desalination, 2005, 178(1–3): 107–113

    Article  CAS  Google Scholar 

  8. Bernhard M, Müller J, Knepper T P. Biodegradation of persistent polar pollutants in wastewater: Comparison of an optimized labscale membrane bioreactor and activated sludge treatment. Water Research, 2006, 40(18): 3419–3428

    Article  CAS  Google Scholar 

  9. Kimura K, Hara H, Watanabe Y. Removal of pharmaceutical compounds by submerged membrane bioreactors (MBRs). Desalination, 2005, 178(1–3): 135–140

    Article  CAS  Google Scholar 

  10. Ternes T A, Joss A, Siegrist H. Scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environmental Science & Technology, 2004, 38(20): 392A–399A

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Longli Bo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bo, L., Urase, T. & Wang, X. Biodegradation of trace pharmaceutical substances in wastewater by a membrane bioreactor. Front. Environ. Sci. Eng. China 3, 236–240 (2009). https://doi.org/10.1007/s11783-009-0004-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11783-009-0004-9

Keywords

Navigation