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Rheological characteristics of drug-loaded microemulsions and their printability in three dimensional printing systems

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Abstract

Rheological properties of microemulsions (MEs) and their printability in three dimensional printing (3DP) systems were investigated. A series of MEs with different contents of oil phase were prepared using sonication method with ibuprofen as model drug and soybean lecithin as emulfier. Stationary and transient rheological properties of MEs were investigated by ARES-SRF using concentric cylinders measuring systems. 3DP systems with piezoelectric drop-on-demand print heads were employed to test the printability of the MEs. Results demonstrate that the apparent viscosity and dynamic linear viscoelastic regions of the MEs are the most important parameters for continuous and stable printing of MEs by 3DP. The incorporation of drug in the MEs has little influence on the MEs’ stationary rheological behaviors and dynamic viscoelasticity, but the concentration of oil phase has a strong influence on them. The rheological property of binder liquids has a close relationship with their printability in 3DP system.

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China

    Deng-guang Yu  (余灯广), Wei-xia Yan  (闫伟霞), Si-jun Zhu  (朱思君), Xue-lian Li  (李雪莲) & Li-min Zhu  (朱利民)

  2. Institute for Health Research and Policy, London Metropolitan University, London, N7 8DB, UK

    Chris Branford-white

Authors
  1. Deng-guang Yu  (余灯广)
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  2. Wei-xia Yan  (闫伟霞)
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  3. Si-jun Zhu  (朱思君)
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  4. Xue-lian Li  (李雪莲)
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  5. Chris Branford-white
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  6. Li-min Zhu  (朱利民)
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Corresponding author

Correspondence to Li-min Zhu  (朱利民).

Additional information

Foundation item: Project(B07024) supported by Biomedical Textile Materials “111 Project” from Ministry of Education of China; Project(50773009) supported by the National Natural Science Foundation of China and Project(Grant IRT0526) supported by Program for Changjiang Scholars and Innovative Research Team in University

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Yu, Dg., Yan, Wx., Zhu, Sj. et al. Rheological characteristics of drug-loaded microemulsions and their printability in three dimensional printing systems. J. Cent. South Univ. Technol. 15 (Suppl 1), 88–92 (2008). https://doi.org/10.1007/s11771-008-0321-3

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  • DOI: https://doi.org/10.1007/s11771-008-0321-3

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