Abstract
With sol-gel method, nanometer La-Ti composite oxides were prepared. By means of atomic force microscope, the surface pattern, particle size distribution and specific surface area were studied. The newly prepared nanocrystals of La-Ti composite oxides were used as the catalysts to catalyze the dehydration of external compensated lactic acid to lactide. The lactide product was measured by polarimeter and micropolariscope. The results demonstrate that the ratio between D-lactide and L-lactide will not be equal to 1:1 if nanocrystals of La-Ti composite oxides are used as the catalysts, which implies, that nanocrystals of La-Ti composite oxides may be potential catalysts with a good selectivity.
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ZHOU Zhong-cheng, RUAN Jian-ming, HUANG Bai-yun, LI Ya-jun, ZOU Jian-peng, ZHANG Hai-bo. Preparation and characterization of poly(D, L-lactide) and its porous biomaterials [J]. Journal of Central South University of Technology, 2005, 12(1): 1–4.
WANG Chen-hong, LI Hong, ZHAO Xiao-na. Ring opening polymerization of L-lactide initiated by creatinine[J]. Biomaterials, 2004, 25(27): 5797–5801.
KULKARNI R K, PANI K C, NEUMAN C, LEONARD F. Polylactic acid for surgical implants [J]. Archive Surgery, 1966, 93: 839–843.
RUAN Jian-ming, ZOU Jian-peng, HUANG Bai-yun. Biomaterial science [M]. Beijing: Science Press, 2004. (in Chinese)
MASAKI N, HISASHI O. Manufacture of high pure lactides by depolymerization of lactic acid oligomers and catalysts therefore: Japan, 5310782 [P]. 2000-05-26.
STEVEN-COHEN R M D, PAUL-MITTERMILLER A, ALPH-HOLMES R E M D, KEVIN BRODER W M D. Clinical experience with a new fast-resorbing polymer for bone stabilization in craniofacial surgery [J]. Journal of Craniofacial Surgery, 2006, 17(1): 40–43.
BETTINGER C J, ORRICK B, MISRA A, LANGER R, BORENSTEIN J T. Microfabrication of poly (glycerol-sebacate) for contact guidance applications [J]. Biomaterials, 2006, 27(12): 2558–2565.
OHKITA T, LEE S H. Thermal degradation and biodegradability of poly (lactic acid)/corn starch biocomposites [J]. Journal of Applied Polymer Science, 2006, 100(4): 3009–3017.
CHENG Chao, WANG Yuan-liang. The progress of catalysts for preparation of lactide [J]. Chemical Research and Application, 2007, 19(4): 358–360. (in Chinese)
LIANG Bao-xia, LIU Peng-sheng. Screen of catalysts for preparation of D-, L-lactide [J]. Journal of Xiangtan University: Science Edition, 2004, 26(1): 59–70. (in Chinese)
GU Li, WANG Yuan-liang, YANG Hua, TANG Li-ling, XIA Lie-wen. Surface topography of La-Ti composite oxide nanocrystallines examined with atomic force microscope [J]. Trans Nonferrous Met Soc China, 2003, 13(2): 294–297.
GU Li, WANG Yuan-liang, ZHU Jiu-jin, XIA Lie-wen. The preparation of ultra-pure D, L-lactide catalyzed by nanocrystalline La-Ti composite oxide [C]// Proceedings of International Congress on Biological and Medical Engineering. Singapore: National University of Singapore, 2002: 12–13.
LI Cao, WANG Yuan-liang. Solid super strong acid of SO4 2−/ZnO-SnO2/La3+ act as catalyst for preparation of lactide [J]. Chemistry and Adhesion, 2003(1): 32–36. (in Chinese)
SU Tao, XIN Yu-ying, MA Hua. Preparation of D, L-lactide by air flow of CO2 under ordinal pressure [J]. Fine Chemical Engineering, 1999, 16(3): 41–43. (in Chinese)
LI Xiao-hong, XIONG Cheng-dong. Preparation of poly lactic acid, its copolymer and their application in biomedical science [J]. Macromolecular Bulletin, 1999(1): 24–32. (in Chinese)
LUO Bing-hong, ZHOU Chang-run. Preparation and characterization of monomer for functional poly lactic acid [J]. Acta Scientiarum Nuturalium Universitatis Sunyatseni, 2005, 44(3): 67–70. (in Chinese)
GU Li, WANG Yuan-liang, ZHU Jiu-jin, WU Jun-han. Preparation of La-Ti composite oxide nanocrystal and examination of their surface topography with atomic force microscope [J]. Chinese Chemistry Letters, 2003, 14(4): 429–432.
GU Li. The preparation of composite oxides nanocrystalline and its catalysis for synthesis of lactide and poly lactic acid [D]. Chongqing: Chongqing University, 2002: 45–53. (in Chinese)
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Foundation item: Project(50174059) supported by the National Natural Science Foundation of China; Project(Y406469) supported by Natural Science Foundation of Zhejiang Province
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Gu, L., Li, F., Ma, Hx. et al. Synthesis of optically active lactide catalyzed by nanocrystals of La-Ti composite oxides. J. Cent. South Univ. Technol. 15, 469–473 (2008). https://doi.org/10.1007/s11771-008-0088-6
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DOI: https://doi.org/10.1007/s11771-008-0088-6