Age as a risk factor for breast cancer-related lymphedema: a systematic review

Abstract

Purpose

Breast cancer-related lymphedema (BCRL) has been widely reported in the medical literature. Various patient characteristics, including age, have been investigated as possible risk factors for this disease entity, but the existence and direction of the cause-and-effect relationship are still unclear. In this review, we aimed to evaluate the effect of age on development of BRCL.

Methods

PubMed, Scopus, and Ovid MEDLINE were searched for relevant articles, which were found to be published between 1974 and 2020.

Results

Twenty-six studies involving 19,396 patients were selected. The average age of patients was 54.9. 26 studies were included in the final analysis, and 13 articles reported no association between age and BCRL development.

Conclusions

Though studies presented different findings, the majority did not identify age as a risk factor for development of lymphedema. However, the level of evidence of individual studies was low. In this article, we call attention to the need for uniform design of lymphedema studies and diagnosis.

Implications for Cancer Survivors

All patients should be informed and screened regularly for lymphedema during and after the treatment independent of their age.

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Data availability

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

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Funding

This study was supported in part by the Mayo Clinic Center for Individualized Medicine, the Mayo Clinic Center for Regenerative Medicine and the Plastic Surgery Foundation.

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Authors

Contributions

All authors contributed to the study conception and design. The idea belonged to Antonio Forte. Literature search, data collection and analysis were performed by Gunel Guliyeva, Maria T. Huayllani, and Daniel Boczar. The first draft of the manuscript was written by Gunel Guliyeva and all authors commented on previous versions of the manuscript. Xiaona Lu and Antonio J. Forte commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Antonio Jorge Forte.

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Conflict of interest

The first author: Gunel Guliyeva declares that there is no conflict of interest regarding the publication of this article.

The second author: Maria T. Huayllani declares that there is no conflict of interest regarding the publication of this article.

The third author: Daniel Boczar declares that there is no conflict of interest regarding the publication of this article.

The fourth author: Francisco R. Avila declares that there is no conflict of interest regarding the publication of this article.

The fifth author: Xiaona Lu declares that there is no conflict of interest regarding the publication of this article.

The corresponding author: Antonio J. Forte declares that there is no conflict of interest regarding the publication of this article.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Guliyeva, G., Huayllani, M.T., Boczar, D. et al. Age as a risk factor for breast cancer-related lymphedema: a systematic review. J Cancer Surviv (2021). https://doi.org/10.1007/s11764-021-00994-z

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Keywords

  • Risk factors
  • Breast Cancer
  • Lymphedema
  • Upper limb lymphedema
  • Age
  • Iatrogenic lymphedema