Breast cancer-related lymphedema (BCRL) has been widely reported in the medical literature. Various patient characteristics, including age, have been investigated as possible risk factors for this disease entity, but the existence and direction of the cause-and-effect relationship are still unclear. In this review, we aimed to evaluate the effect of age on development of BRCL.
PubMed, Scopus, and Ovid MEDLINE were searched for relevant articles, which were found to be published between 1974 and 2020.
Twenty-six studies involving 19,396 patients were selected. The average age of patients was 54.9. 26 studies were included in the final analysis, and 13 articles reported no association between age and BCRL development.
Though studies presented different findings, the majority did not identify age as a risk factor for development of lymphedema. However, the level of evidence of individual studies was low. In this article, we call attention to the need for uniform design of lymphedema studies and diagnosis.
Implications for Cancer Survivors
All patients should be informed and screened regularly for lymphedema during and after the treatment independent of their age.
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This study was supported in part by the Mayo Clinic Center for Individualized Medicine, the Mayo Clinic Center for Regenerative Medicine and the Plastic Surgery Foundation.
Conflict of interest
The first author: Gunel Guliyeva declares that there is no conflict of interest regarding the publication of this article.
The second author: Maria T. Huayllani declares that there is no conflict of interest regarding the publication of this article.
The third author: Daniel Boczar declares that there is no conflict of interest regarding the publication of this article.
The fourth author: Francisco R. Avila declares that there is no conflict of interest regarding the publication of this article.
The fifth author: Xiaona Lu declares that there is no conflict of interest regarding the publication of this article.
The corresponding author: Antonio J. Forte declares that there is no conflict of interest regarding the publication of this article.
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Guliyeva, G., Huayllani, M.T., Boczar, D. et al. Age as a risk factor for breast cancer-related lymphedema: a systematic review. J Cancer Surviv (2021). https://doi.org/10.1007/s11764-021-00994-z
- Risk factors
- Breast Cancer
- Upper limb lymphedema
- Iatrogenic lymphedema