Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy

Abstract

Purpose

The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause.

Methods

A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed.

Results

Average adherence to all program components was 74.8 %. Women in the intervention group maintained their cardiovascular fitness level over the 12 months (1.1 ± 7.9 %), while the control group significantly decreased fitness capacity (−4.0 ± 7.5 %). There was a significant difference between groups in percent change of whole body bone area (−0.8 ± 2.5 control and 0.5 ± 1.30 intervention). We also observed decreased BMI (−4.7 ± 6.2 %) and fat mass (−8.6 ± 12.7 %) in the intervention group due to significant concomitant decreases in caloric intake and increases in caloric expenditure. The control group demonstrated decreased caloric intake and decreased lean tissue mass.

Conclusions

In this population at high risk for detrimental cardiovascular and bone outcomes, a commercially available lifestyle intervention program mitigated a decline in cardiovascular health, improved bone health, and decreased weight through fat loss.

Implications for cancer survivors

Precision Nutrition Coaching has shown benefit in breast cancer survivors for reduced risk of deleterious cardiovascular and bone outcomes.

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Acknowledgements

The project described was supported by the Basser Research Center for BRCA and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR000003.

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Corresponding author

Correspondence to Kathryn Schmitz.

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Funding

The project described was supported by the Basser Research Center for BRCA and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR000003. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Conflict of interest

David Sarwer discloses that he has consulting relationships with BARONova, Enteromedics, Kythera, Medtronic, and Neothetics. These relationships have no relationship to this study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Sturgeon, K.M., Dean, L.T., Heroux, M. et al. Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy. J Cancer Surviv 11, 246–255 (2017). https://doi.org/10.1007/s11764-016-0582-z

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Keywords

  • Neoplasm
  • Exercise
  • Heart
  • Bone
  • Weight loss
  • BRCA1/2