Levels of fatigue and distress in senior prostate cancer survivors enrolled in a 12-week randomized controlled trial of Qigong
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Fatigue is a commonly reported symptom by prostate cancer survivors and is associated with significant distress and declines in quality of life. Qigong is a mind–body activity that consists of both physical activity and meditative aspects. This 12-week randomized controlled trial examined the feasibility and efficacy of a Qigong intervention for improving older prostate cancer survivors' levels of fatigue and distress.
Forty older (median age = 72, range = 58–93), fatigued (cut-off value of ≥1 on the CTCAEv4.0, >20 on a fatigue grading scale), and sedentary (<150 min of moderate exercise/week) prostate cancer survivors were randomized to 12 weeks of Qigong or stretching classes. Primary outcomes were feasibility (i.e., retention and class attendance rates) and fatigue [Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-Fatigue)], and secondary outcome was distress [Brief Symptom Inventory-18 (BSI-18)].
Study retention rates did not significantly differ between study groups (Qigong = 80 %, stretching = 65 %, p = 0.48). The Qigong group had significantly higher class attendance than the stretching group (p = 0.04). The Qigong group had significantly greater improvements in the FACIT-Fatigue (p = 0.02) and distress (i.e., BSI-18 Somatization, Anxiety, & Global Severity Index, p's < 0.05), than the Stretching group.
This 12-week Qigong intervention was feasible and potentially efficacious in improving senior prostate cancer survivors' levels of fatigue and distress levels. Future, larger definitive randomized controlled trials are needed to confirm these benefits in older prostate cancer survivors and in racially and ethnically diverse populations.
Implications for cancer survivors
Qigong may be an effective nonpharmacological intervention for the management of senior prostate cancer survivors' fatigue and distress.
KeywordsSenior prostate cancer survivors Qigong Randomized controlled trial Fatigue Distress
- 1.Society AC. Cancer facts & figures 2010. Atlanta: American Cancer Society; 2010.Google Scholar
- 2.Altekruse SF KC, Krapcho M, Neyman N, Aminou R, Waldron W, Ruhl J, Howlader N, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Cronin K, Chen HS, Feuer EJ, Stinchcomb DG, Edwards BK. SEER cancer statistics review. National Cancer Institute. 2009. 2011.Google Scholar
- 3.Joly F, Alibhai SM, Galica J, Park A, Yi QL, Wagner L, et al. Impact of androgen deprivation therapy on physical and cognitive function, as well as quality of life of patients with nonmetastatic prostate cancer. J Urol. 2006;176(6 Pt 1):2443–7. doi:10.1016/j.juro.2006.07.151.CrossRefPubMedGoogle Scholar
- 4.Rao A, Cohen HJ. Symptom management in the elderly cancer patient: fatigue, pain, and depression. J Natl Cancer Inst Monogr. 2004(32):150–7. doi:10.1093/jncimonographs/lgh031 2004/32/150 [pii].
- 5.National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Cancer-Related Fatigue. Version 1.2013. Fort Washington: National Comprehensive Cancer Network; 2012.Google Scholar
- 8.Rao AV, Demark-Wahnefried W. The older cancer survivor. Crit RevOncolHematol. 2006;60(2):131–43.Google Scholar
- 10.National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Distress Management; 2012.Google Scholar
- 23.CDC. Fact sheet for health professionals on physical activity guidelines for older adults. Atlanta: US Department of Health and Human Services; 2008.Google Scholar
- 24.Hussain M, Tangen CM, Higano C, Schelhammer PF, Faulkner J, Crawford ED, et al. Absolute prostate-specific antigen value after androgen deprivation is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162). J Clin Oncol. 2006;24(24):3984–90. doi:10.1200/JCO.2006.06.4246.CrossRefPubMedGoogle Scholar
- 30.Derogatis LR. BSI 18 Brief Symptom Inventory 18, administration, scoring, and procedures manual. Minneapolis: NCS Pearson; 2000.Google Scholar
- 35.Oh B, Butow PN, Mullan BA, Clarke SJ, Beale PJ, Pavlakis N, et al. Effect of medical Qigong on cognitive function, quality of life, and a biomarker of inflammation in cancer patients: a randomized controlled trial. Support Care Cancer. 2012;20(6):1235–42. doi:10.1007/s00520-011-1209-6.CrossRefPubMedGoogle Scholar
- 37.Ho RT, Chan JS, Wang CW, Lau BW, So KF, Yuen LP, et al. A randomized controlled trial of Qigong exercise on fatigue symptoms, functioning, and telomerase activity in persons with chronic fatigue or chronic fatigue syndrome. Ann Behav Med. 2012;44(2):160–70. doi:10.1007/s12160-012-9381-6.PubMedCentralCrossRefPubMedGoogle Scholar
- 41.Garland SN, Tamagawa R, Todd SC, Speca M, Carlson LE. Increased mindfulness is related to improved stress and mood following participation in a mindfulness-based stress reduction program in individuals with cancer. Integr Cancer Ther. 2013;12:31–40. doi:10.1177/1534735412442370.CrossRefPubMedGoogle Scholar