Abstract
Objective
This single-center retrospective study evaluated early and midterm outcomes of 100 consecutive patients with type A intramural hematoma.
Methods
Initial watch-and-wait strategy was indicated if the maximum aortic diameter was < 50 mm, pain score was < 3/10 on the numerical rating scale, and no ulcer-like projection was observed in the ascending aorta. The primary endpoints of this study were all-cause and aorta-related deaths, and the secondary endpoint was aortic events.
Results
Initial watch-and-wait strategy was indicated in 52 patients. Emergency aortic repair was indicated in the remaining 48 patients; 2, 31, and 15 patients died before surgery, underwent emergency surgery, and declined emergency surgery, respectively. Among the watch-and-wait group, 11 (21%) patients underwent aortic repair during hospitalization. In-hospital mortality rates, 5-year survival rates, and 5-year freedom from aorta-related death were not significantly different between the initial watch-and-wait strategy and emergency surgery (2% vs. 6%, 92% vs. 82%, and 100% vs. 94%, respectively). In the initial watch-and-wait strategy group, 5-year freedom from aortic events and freedom from aortic events involving the ascending aorta were 60% and 66%, respectively.
Conclusions
The early and midterm outcomes with the initial watch-and-wait strategy in patients with type A intramural hematoma with a maximum aortic diameter of ≤ 50 mm, pain score of ≤ 3/10, and no ulcer-like projection in the ascending aorta were favorable with no aorta-related death.
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References
Vilacosta I, San Román JA, Ferreirós J, et al. Natural history and serial morphology of aortic intramural hematoma: a novel variant of aortic dissection. Am Heart J. 1997;134:495–507.
Valente T, Sica G, Bocchini G, et al. MDCT imaging of non-traumatic thoracic aortic emergencies and its impact on diagnosis and management–A reappraisal. Tomography. 2022;8:200–28.
Kitamura T, Torii S, Miyamoto T, et al. Watch-and-wait strategy for type A intramural haematoma and acute aortic dissection with thrombosed false lumen of the ascending aorta: a Japanese single-centre experience. Eur J Cardiothorac Surg. 2020;58:590–7.
Song JK, Yim JH, Ahn JM, et al. Outcomes of patients with acute type A aortic intramural hematoma. Circulation. 2009;120:2046–52.
Chow SCY, Wong RHL, Lakhani I, et al. Management of acute type A intramural hematoma: upfront surgery or individualized approach? A retrospective analysis and meta-analysis. J Thorac Dis. 2020;12:680–9.
Kitai T, Kaji S, Yamamuro A, et al. Clinical outcomes of medical therapy and timely operation in initially diagnosed type A aortic intramural hematoma: a 20-year experience. Circulation. 2009;120:S292–8.
Harris KM, Braverman AC, Eagle KA, et al. Acute aortic intramural hematoma: an analysis from the international registry of acute aortic dissection. Circulation. 2012;126:S91–6.
Isselbacher EM, Preventza O, Hamilton Black J III, et al. ACC/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association/American College of Cardiology joint committee on clinical practice guidelines. Circulation. 2022;2022(146):e334–482.
Sandhu HK, Tanaka A, Charlton-Ouw KM, et al. Outcomes and management of type A intramural hematoma. Ann Cardiothorac Surg. 2016;5:317–27.
Czerny M, Schmidli J, Adler S, et al. Current options and recommendations for the treatment of thoracic aortic pathologies involving the aortic arch: an expert consensus document of the European Association for Cardio-Thoracic Surgery (EACTS) and the European Society for Vascular Surgery (ESVS). Eur J Cardiothorac Surg. 2019;55:133–62.
Yamada T, Tada S, Harada J. Aortic dissection without intimal rupture: diagnosis with MR imaging and CT. Radiology. 1988;168:347–52.
Wee I, Varughese RS, Syn N, et al. Non-operative management of type A acute aortic syndromes: a systematic review and meta-analysis. Eur J Vasc Endovasc Surg. 2019;58:41–51.
JCS Joint Working Group. Guidelines for diagnosis and treatment of aortic aneurysm and aortic dissection (JCS 2011): digest version. Circ J. 2013;77:789–828.
Nakamae K, Oshitomi T, Uesugi H, et al. Noncommunicating acute type A aortic dissection in elderly patients: surgery versus medical management. Eur J Cardiothorac Surg. 2022;62:484.
Attia R, Young C, Fallouh HB, et al. In patients with acute aortic intramural haematoma is open surgical repair superior to conservative management? Interact Cardiovasc Thorac Surg. 2009;9:868–71.
Evangelista A, Dominguez R, Sebastia C, et al. Prognostic value of clinical and morphologic findings in short-term evolution of aortic intramural haematoma. Therapeutic implications. Eur Heart J. 2004;25:81–7.
Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs. 2005;14:798–804.
Bijur PE, Latimer CT, Gallagher EJ. Validation of a verbally administered numerical rating scale of acute pain for use in the emergency department. Acad Emerg Med. 2003;10:390–2.
Minotti B, Mansella G, Sieber R, et al. Intravenous acetaminophen does not reduce morphine use for pain relief in emergency department patients: a multicenter, randomized, double-blind, placebo-controlled trial. Acad Emerg Med. 2022;29:954–62.
Ueda T, Chin A, Petrovitch I, et al. A pictorial review of acute aortic syndrome: discriminating and overlapping features as revealed by ECG-gated multidetector-row CT angiography. Insights Imaging. 2012;3:561–71.
Kitamura T, Miyaji K. Emergency pericardial drainage without aortic repair for type A intramural haematoma complicated by cardiac tamponade. Interact Cardiovasc Thorac Surg. 2021;32:953–5.
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Supplementary file1 Supplemental Video 1. Intraoperative video of cases with acute type A aortic dissection and IMH complicated by cardiac tamponade without aortic rupture (MP4 37336 KB)
Supplementary file2 Supplemental Video 2. Intraoperative video of a patient with type A IMH with a ULP in the ascending aorta who developed massive bleeding from the ascending aorta following heparin administration (MP4 47527 KB)
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Kitamura, T., Fukuzumi, M., Mishima, T. et al. Watch-and-wait strategy for selected patients with type A intramural hematoma. Gen Thorac Cardiovasc Surg 72, 225–231 (2024). https://doi.org/10.1007/s11748-023-01967-y
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DOI: https://doi.org/10.1007/s11748-023-01967-y