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Prognostic factors for pulmonary carcinoid with positive lymph node after surgical resection: a SEER database study

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Abstract

Background

Prognostic factors and role with chemotherapy (CT) and radiotherapy (RT) remain unclear for patients of pulmonary carcinoid (PC) with positive lymph node after surgery.

Methods

PC patients who underwent surgery and with positive lymph node between 2000 and 2016 were identified from the SEER database. Univariate and multivariate cox regression analysis were used to identify independent risk factors for overall survival (OS).

Results

A total of 552 patients were identified. Multivariate analysis indicated that age (≤ 70/ > 70) (HR = 0.32, 95% CI 0.21–0.50; P < 0.001), histologic type (typical carcinoid [TC]/atypical carcinoid [AC]) (HR = 0.53, 95% CI 0.36–0.78, P = 0.001), number of positive lymph nodes (n ≥ 3/n = 1–2) (HR = 1.91, 95% CI 1.26–2.90; P = 0.002), and treatment mode (surgery + RT/surgery alone) (HR = 1.75, 95% CI 1.09–2.81; P 0.02) were independent prognostic factors for OS. In subgroup analysis according to histological type, prognostic factors were similar between AC and TC, except surgery + RT being negative prognostic factor for TC but AC. No significant difference in OS was observed between the surgery alone and surgery + CT in any subgroup of patients.

Conclusions

Age > 70, histological type of AC, positive lymph nodes ≥ 3, and surgery + RT were likely to be negative prognostic factors for OS. Addition CT to surgery did not appear to provide additional OS benefit.

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Data Availability

The data used in this study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors thank SEER database for its public availability.

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Authors and Affiliations

  1. Department of Radiation Oncology, The First Hospital of China Medical University, 155 Nanjing Road, Heping District, Shenyang, 110001, China

    Xiaoling Wang & Jun Dang

  2. Department of Radiation Oncology, Anshan Cancer Hospital, Anshan, China

    Tingting Liu

  3. Department of Radiation Oncology, Shenyang Tenth People’s Hospital, Shenyang, China

    Jun Chen

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  1. Xiaoling Wang
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  2. Tingting Liu
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  3. Jun Chen
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  4. Jun Dang
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Contributions

Conception and design: JD. Collection and assembly of data: XW and TL. Data analysis and interpretation: all authors. Manuscript writing: all authors. Final approval of manuscript: all authors.

Corresponding author

Correspondence to Jun Dang.

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Conflict of interest

All authors declare that they have no conflict of interests.

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Institutional review board approval was not necessary, because data of the SEER database are publicly available and do not contain identifiable patient information.

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Wang, X., Liu, T., Chen, J. et al. Prognostic factors for pulmonary carcinoid with positive lymph node after surgical resection: a SEER database study. Gen Thorac Cardiovasc Surg 71, 409–417 (2023). https://doi.org/10.1007/s11748-023-01910-1

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  • DOI: https://doi.org/10.1007/s11748-023-01910-1

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