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Optimal settings of near-infrared fluorescence imaging with indocyanine green for intraoperative detection of lymph node metastasis in esophageal cancer

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Abstract

Lymphatic flow mapping using near-infrared fluorescence (NIR) imaging with indocyanine green (ICG) has been used for intraoperative diagnosis of lymph node metastasis (LNM) in various cancers. Accurate prediction of LNM intraoperatively may allow minimization of the extent of lymphadenectomy. However, a consistent method and diagnostic ability, allowing application of NIR-guided lymphatic flow mapping to esophageal cancer (EC), have not been established due to the multidirectional and complex characteristics of lymphatic flow in the esophagus. Herein, we present a novel NIR-guided surgical technique for predicting lymph node stations potentially containing LNM in EC with high diagnostic accuracy derived from appropriately adjusting the ICG injection setting.

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Acknowledgements

We thank past and present members of our department for collecting the data used for this analysis from the early period of the study.

Funding

This research received no specific grants from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Shinichiro Shiomi, Koichi Yagi & Yasuyuki Seto

  2. Department of Gastrointestinal Surgery, Nihon University Hospital, 1-6 Surugadai, Chiyoda-ku, Tokyo, 101-8309, Japan

    Ryohei Iwata & Hiroharu Yamashita

  3. Department of Surgery, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-0071, Japan

    Susumu Aikou

Authors
  1. Ryohei Iwata
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  2. Shinichiro Shiomi
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  3. Susumu Aikou
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  4. Koichi Yagi
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  5. Hiroharu Yamashita
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  6. Yasuyuki Seto
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Correspondence to Yasuyuki Seto.

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Iwata, R., Shiomi, S., Aikou, S. et al. Optimal settings of near-infrared fluorescence imaging with indocyanine green for intraoperative detection of lymph node metastasis in esophageal cancer. Gen Thorac Cardiovasc Surg 70, 924–929 (2022). https://doi.org/10.1007/s11748-022-01859-7

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  • DOI: https://doi.org/10.1007/s11748-022-01859-7

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