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Lobe-specific nodal dissection with intraoperative frozen section analysis for clinical stage-I non-small cell lung cancer: a validation study by propensity score matching

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Abstract

Objective

Lobe-specific nodal dissection (LND) is increasingly used for non-small cell lung cancer (NSCLC) in Japan; however, its treatment validity remains unclarified. Since 2013, LND has been used as a standard procedure for clinical stage-I (c-stage-I) NSCLC at our institution. We aimed to evaluate its validity using intraoperative frozen section analysis (FSA) for c-stage-I NSCLC.

Methods

The participants comprised patients with NSCLC who underwent LND between 2013 and 2016 (n = 307) or systematic nodal dissection (SND) between 2002 and 2013 (n = 367) for c-stage-I disease. FSA was routinely performed in LND to examine at least three stations. Outcomes were compared between the LND and SND groups. Patients in whom LND was converted to SND due to metastasis on FSA of the sampled lymph node were still categorized into the LND group, i.e., intention-to-treat analysis. The prognostic impact was compared using propensity score matching.

Results

The rate of conversion from LND to SND was 10.4%. Of the patients converted to SND, 12.5% had metastases outside the LND area. False-negative N2 results were detected in only 0.7% of the LND group patients after FSA. After matching, each group had 220 patients. There were no significant between-group differences in the lymph-node recurrence rate (7% vs. 6%), 5-year recurrence-free survival (80.1% vs. 79.0%), and overall survival (90.4% vs. 90.3%).

Conclusions

LND with intraoperative FSA is a valid modality that could serve as a standard surgical procedure for c-stage-I NSCLC. Intraoperative FSA may lower the residual lymph-node metastasis risk in LND.

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Authors and Affiliations

  1. Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan

    Mitsuhiro Isaka, Hideaki Kojima, Hayato Konno, Tetsuya Mizuno, Toshiyuki Nagata, Shinya Katsumata & Yasuhisa Ohde

  2. Clinical Research Promotion Unit, Clinical Research Center, Shizuoka Cancer Center, Japan

    Toru Imai

  3. Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan

    Takuya Kawata & Takashi Nakajima

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  1. Mitsuhiro Isaka
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  2. Hideaki Kojima
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Correspondence to Mitsuhiro Isaka.

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Isaka, M., Kojima, H., Imai, T. et al. Lobe-specific nodal dissection with intraoperative frozen section analysis for clinical stage-I non-small cell lung cancer: a validation study by propensity score matching. Gen Thorac Cardiovasc Surg 70, 977–984 (2022). https://doi.org/10.1007/s11748-022-01827-1

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