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Differential impacts of postoperative complications on patients’ survival in completely resected non-small-cell lung cancer

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Abstract

Objective

The aim of this study was to investigate the effects of inflammatory respiratory complications on long-term survival in patients with resected non-small cell lung cancer. We defined inflammatory respiratory complications to include the following six conditions: pneumonia, empyema, bronchial fistula, respiratory dysfunction, acute interstitial pneumonia, and atelectasis.

Methods

Part of the National Clinical Database was linked to our prospective database from 2014 to 2017. Linkage was achieved for 866 patients. The Kaplan–Meier method was used to evaluate the overall, relapse-free, and cancer-related survival. The Cox proportional hazard model was used to analyze the impact of each complication.

Results

Of the 736 patients included in the study, 149 had complications. The 5-year overall and cancer-specific survival rates were significantly lower in patients with inflammatory respiratory complications. The Cox proportional hazard model showed that the inflammatory respiratory complications had a significant impact on overall survival (hazard ratio 2.48, 95% confidence interval 1.41–4.38) but not air leak (hazard ratio 1.38, 95% confidence interval 0.70–2.70).

Conclusions

Our study shows the differential impact of each complication on the survival of patients with non-small cell lung cancer. The presence of inflammatory respiratory complications was the only predictor of poor overall survival.

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Acknowledgements

We thank all the staff members of the Department of Thoracic Surgery, Nagoya Graduate School of Medicine, and Dr. Kota Ono (https://ono-biostat-consulting.com/), also an employee of AbbVie GK.

Funding

The authors received no funding assistance for this study.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yuka Kadomatsu, Hideki Tsubouchi, Keita Nakanishi, Tomoshi Sugiyama, Harushi Ueno, Masaki Goto, Naoki Ozeki, Shota Nakamura, Takayuki Fukui & Toyofumi Fengshi Chen-Yoshikawa

Authors
  1. Yuka Kadomatsu
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  2. Hideki Tsubouchi
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  3. Keita Nakanishi
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  4. Tomoshi Sugiyama
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  5. Harushi Ueno
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  6. Masaki Goto
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  7. Naoki Ozeki
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  8. Shota Nakamura
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  9. Takayuki Fukui
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  10. Toyofumi Fengshi Chen-Yoshikawa
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Corresponding author

Correspondence to Yuka Kadomatsu.

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Kadomatsu, Y., Tsubouchi, H., Nakanishi, K. et al. Differential impacts of postoperative complications on patients’ survival in completely resected non-small-cell lung cancer. Gen Thorac Cardiovasc Surg 69, 1283–1290 (2021). https://doi.org/10.1007/s11748-021-01619-z

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  • DOI: https://doi.org/10.1007/s11748-021-01619-z

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