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The impact of perioperative heparin bridging therapy in lung cancer surgery

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Abstract

Purpose

The impact of perioperative heparin bridging (HB) for lung surgery in patients on anti-clotting drugs remains unclear. We performed a retrospective study to assess its effect on surgical safety by comparing HB and non-HB groups.

Methods

This study included 274 consecutive patients on anti-clotting drugs who underwent surgery for lung cancer. Of these, 77 received HB and 197 did not. Propensity score matching extracted 124 patients, consisting of 62 patients with HB and 62 patients without HB. Endpoints were surgical safety.

Results

There was no statistically significant difference in the outcomes of surgical safety outcomes between the HB and non-HB group after propensity-score matching, operative time (172 vs. 203 min, p = 0.131), volume of blood loss (60 vs. 70 ml, p = 0.335), need for intraoperative RBC transfusion (3.2 vs. 6.5%, p = 0.680), chest tube drainage volume on the 1st postoperative day (200 vs. 200 ml, p = 0.796), and chest tube placement duration (3 vs. 3 days, p = 0.606).

Conclusions

The influence of perioperative HB on postoperative thromboembolic or bleeding events in lung cancer surgery is not obvious, but its surgical safety appears to be acceptable.

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Authors and Affiliations

  1. Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan

    Masataka Mori, Masatoshi Kanayama, Akihiro Taira, Shinji Shinohara, Taiji Kuwata, Naoko Imanishi, Kazue Yoneda, Koji Kuroda & Fumihiro Tanaka

  2. Department of General Thoracic Surgery, National Hospital Organization Saitama Hospital, Wako, Japan

    Yoshinobu Ichiki

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  1. Masataka Mori
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  2. Yoshinobu Ichiki
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  3. Masatoshi Kanayama
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  4. Akihiro Taira
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  5. Shinji Shinohara
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  10. Fumihiro Tanaka
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Correspondence to Masataka Mori.

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Mori, M., Ichiki, Y., Kanayama, M. et al. The impact of perioperative heparin bridging therapy in lung cancer surgery. Gen Thorac Cardiovasc Surg 68, 623–628 (2020). https://doi.org/10.1007/s11748-019-01276-3

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  • DOI: https://doi.org/10.1007/s11748-019-01276-3

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