Skip to main content

Ciliated muconodular papillary tumor of the lung: a case report and literature review

General Thoracic and Cardiovascular Surgery volume 68, pages 1344–1349 (2020)Cite this article

Abstract

Ciliated muconodular papillary tumor (CMPT) of the lung is characterized as a peripheral low-grade malignant tumor with ciliated columnar cells and goblet cells with basaloid cell proliferation. Herein, we report on a case of CMPT with a radiologically abnormal shadow which was reminiscent of adenocarcinoma. The patient underwent right S6 + S8a segmentectomy because an intraoperative biopsy suggested CMPT, the malignancy of which was difficult to distinguish; however, the tumor was small and located in the peripheral lung. Many details of this tumor remain unclear, as CMPT is a rare tumor with few reports. CMPT has therefore not yet been classified by the WHO. In this report, we will consider the characteristics of CMPT and treatment based on our case and previous case reports.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2

References

  1. Ishikawa Y. Ciliated muconodular papillary tumor of the peripheral lung: benign or malignant? Pathol Clin Med (in Japanese). 2002;20:964–5.

    Google Scholar 

  2. Sato S, Koike T, Homma K, Yokoyama A. Ciliated muconodular papillary tumour of the lung: a newly defined low-grade malignant tumour. Interact Cardiovasc Thorac Surg. 2010;11:685–7.

    Article  Google Scholar 

  3. Hata Y, Yuasa R, Sato F, Otsuka H, Goto H, Isobe K, et al. Ciliated muconodular papillary tumor of the lung: a newly defined low-grade malignant tumor with CT findings reminiscent of adenocarcinoma. Jpn J Clin Oncol. 2013;43:205–7.

    Article  Google Scholar 

  4. Ishikawa Y, Kameda Y, Tajiri M, Omori T, Nagashima T, Kojima Y, et al. A case of ciliated muconodular papillary tumor of the lung originating in left lower lobe. Jpn J Lung Cancer (in Japanese). 2013;53:817–8.

    Article  Google Scholar 

  5. Yuki D, Kawano O, Fukai I, Uchiyama T, Baba Y, Murata T. A surgical case of ciliated muconodular papillary tumor that required additional exploration to distinguish it from mucinous adenocarcinoma in situ. Jpn J Lung Cancer (in Japanese). 2013;53:831–5.

    Article  Google Scholar 

  6. Chuang HW, Liao JB, Chang HC, Wang JS, Lin AL, Hsieh PP. Ciliated muconodular papillary tumor of the lung: a newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: a case report and review of literature. Pathol Int. 2014;64:352–7.

    CAS  Article  Google Scholar 

  7. Kamata T, Sunami K, Yoshida A, Shiraishi K, Furuta K, Shimada Y, et al. Frequent BRAF or EGFR mutations in ciliated muconodular papillary tumors of the lung. J Thorac Oncol. 2016;11:261–5.

    Article  Google Scholar 

  8. Kon T, Baba Y, Fukai I, Watanabe G, Uchiyama T, Murata T. Ciliated muconodular papillary tumor of the lung: a report of five cases. Pathol Int. 2016;66:633–9.

    Article  Google Scholar 

  9. Ishikawa M, Sumitomo S, Imamura N, Nishida T, Mineura K, Ono K. Ciliated muconodular papillary tumor of the lung: report of five cases. J Surg Case Rep. 2016;8:1–4.

    Google Scholar 

  10. Lau KW, Aubry MC, Tan GS, Lim CH, Takano AM. Ciliated muconodular papillary tumor: a solitary peripheral lung nodule in a teenage girl. Hum Pathol. 2016;49:22–6.

    Article  Google Scholar 

  11. Liu L, Aesif SW, Kippo BR, Voss JS, Daniel S, Aubry MC, et al. Ciliated muconodular papillary tumors of the lung can occur in western patients and show mutations in BRAF and AKT1. Am J Surg Pathol. 2016;40:1631–6.

    Article  Google Scholar 

  12. Segawa M, Toki Y, Shimada Y, Tatsu H, Saito K, Touge M. Ciliated muconodular papillary tumor of the lung. Jpn J Thoracic Cardiovasc Surg (in Japanese). 2017;70:782–5.

    Google Scholar 

  13. Matsuoka S, Kondo R, Ishii K. Differential diagnosis of a rare papillary tumor and mucinous adenocarcinoma. Asian Cardiovasc Thorac Ann. 2017;25:391–4.

    Article  Google Scholar 

  14. Jin Y, Shen X, Shen L, Sun Y, Chen H, Li Y. Ciliated muconodular papillary tumor of the lung harboring ALK gene rearrangement: case report and review of the literature. Pathol Int. 2017;67:171–5.

    CAS  Article  Google Scholar 

  15. Kim L, Kim YS, Lee JS, Choi SJ, Park IS, Hanet JY, et al. Ciliated muconodular papillary tumor of the lung harboring BRAF V600E mutation and p16INK4a overexpression without proliferative activity may represent an example of oncogene-induced senescence. J Thorac Dis. 2017;9:E1039–E10441044.

    Article  Google Scholar 

  16. Taguchi R, Higuchi K, Sudo M, Misawa K, Miyamoto T, Mishima O, et al. A case of anaplastic lymphoma kinase (ALK)-positive ciliated muconodular papillary tumor (CMPT) of the lung. Pathol Int. 2017;67:99–104.

    Article  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Thoracic and Breast Surgery, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan

    Miyuki Abe, Atsushi Osoegawa, Michiyo Miyawaki, Daiki Noda, Takashi Karashima, Yohei Takumi, Takafumi Hashimoto, Tatsuro Okamoto & Kenji Sugio

  2. Department of Diagnostic Pathology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan

    Tsutom Daa

Authors
  1. Miyuki Abe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Atsushi Osoegawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michiyo Miyawaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daiki Noda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takashi Karashima
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yohei Takumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takafumi Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Tatsuro Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Tsutom Daa
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kenji Sugio
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kenji Sugio.

Ethics declarations

Conflict of interest

The authors have declared that no conflict of interest exists.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Abe, M., Osoegawa, A., Miyawaki, M. et al. Ciliated muconodular papillary tumor of the lung: a case report and literature review. Gen Thorac Cardiovasc Surg 68, 1344–1349 (2020). https://doi.org/10.1007/s11748-019-01252-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11748-019-01252-x

Keywords

  • Ciliated muconodular papillary tumor
  • Low-grade malignancy
  • Lung tumor
  • CMPT
  • Segmentectomy