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Quantitative computed tomography for predicting cardiopulmonary complications after lobectomy for lung cancer in patients with chronic obstructive pulmonary disease

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Abstract

Objectives

In lung cancer resection, chronic obstructive pulmonary disease is a risk factor for post-operative complications. Few studies on post-operative complications of lung cancer resection have considered radiographic emphysematous change as an index. Here, we have examined the relationship between the regional ratio of the emphysematous area in pre-operative computed tomography images and cardiopulmonary complications in patients with chronic obstructive pulmonary disease who underwent lung cancer resection.

Methods

We retrospectively evaluated 159 patients with chronic obstructive pulmonary disease who underwent lobectomy for lung cancer at Shizuoka Cancer Center Hospital, Shizuoka, Japan, between 2002 and 2011. Pre-operative factors, including the proportion of the emphysematous area measured by computed tomography as a percentage of the low attenuation area (LAA%), as well as intraoperative factors were analyzed. Cardiopulmonary complications, including pyothorax, pneumonia and atelectasis, acute pulmonary injury, indwelling chest tube, long duration of oxygen supply, and arrhythmia, were evaluated.

Results

Cardiopulmonary complications were observed among 61 patients (38%). Univariate analysis revealed that patient age, percentage of forced expiratory volume in 1 s, LAA%, and volume of blood loss were significantly associated with cardiopulmonary complications. Multivariate analysis indicated patient age and LAA% as being significant independent predictors of cardiopulmonary complications.

Conclusions

The regional ratio of the emphysematous area is useful for predicting cardiopulmonary complications in patients with chronic obstructive pulmonary disease who undergo lobectomy for lung cancer. In such patients who are also ≥ 70 years of age and exhibit LAA% ≥ 1.0%, careful intra- and post-operative management is warranted.

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Funding

This study did not receive outside financial support.

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Authors and Affiliations

  1. Division of Thoracic Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan

    Yoshiyuki Yasuura, Naoko Miyata, Kiyomichi Mizuno, Reiko Shimizu, Hiroyuki Kayata, Hideaki Kojima, Mitsuhiro Isaka & Yasuhisa Ohde

  2. Division of Thoracic Surgery, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, Japan

    Tomohiro Maniwa

  3. Clinical Trial Coordination Office, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan

    Keita Mori

Authors
  1. Yoshiyuki Yasuura
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  2. Tomohiro Maniwa
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  3. Keita Mori
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  4. Naoko Miyata
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  5. Kiyomichi Mizuno
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  7. Hiroyuki Kayata
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  8. Hideaki Kojima
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  9. Mitsuhiro Isaka
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  10. Yasuhisa Ohde
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Correspondence to Yoshiyuki Yasuura.

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Yasuura, Y., Maniwa, T., Mori, K. et al. Quantitative computed tomography for predicting cardiopulmonary complications after lobectomy for lung cancer in patients with chronic obstructive pulmonary disease. Gen Thorac Cardiovasc Surg 67, 697–703 (2019). https://doi.org/10.1007/s11748-019-01080-z

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  • DOI: https://doi.org/10.1007/s11748-019-01080-z

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