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General Thoracic and Cardiovascular Surgery

, Volume 66, Issue 6, pp 344–350 | Cite as

The influence of comorbidity on the postoperative survival in elderly (≥ 75 years old) with lung cancer

  • Tokujiro Yano
  • Mototsugu Shimokawa
  • Osamu Kawashima
  • Mitsuhiro Takenoyama
  • Yoshinori Yamashita
  • Takeshi Fukami
  • Tsuyoshi Ueno
  • Eiji Yatsuyanagi
  • Seiichi Fukuyama
  • For the National Hospital Organization Network Collaborative Research—Thoracic Oncology Group
Original Article
  • 145 Downloads

Abstract

Objectives

We conducted a multi-institutional prospective observational study of elderly patients (≥ 75 years-old) with resected non-small cell lung cancer. In this report, we have followed the cohorts for 2 years after surgery and examined both the influence of preoperative comorbidity [Adult Comorbidity Evaluation-27 (ACE-27) index] on the postoperative survival and the change in the Karnofsky Performance Status (KPS).

Methods

From March 2014 to April 2015, 264 patients were prospectively registered from 22 hospitals affiliated with the National Hospital Organization. The mean age at the time of surgery was 79.3 years (range 75–90 years), and 41% of the patients were ≥ 80 years of age. A total of 26% underwent sublobar resection. The study endpoints were the postoperative overall survival (OS), its prognostic factors, and the changes in the postoperative KPS.

Results

The 2-year OS was 85.3% (95% confidence interval 80.4–89.1%). Male gender, age ≥ 80, a smoking history, grade 2 of ACE-27, and an advanced disease stage were significantly poor prognostic factors for the OS in the univariate risk analysis. The multivariate analysis showed that male gender, age ≥ 80, an advanced disease stage and sublobar resection were significantly poor prognostic factors for the OS. In comparison with the preoperative KPS, no marked decline was observed in the postoperative chorological change of KPS.

Conclusions

In the surgical treatment of elderly patients, the comorbidity as assessed by the ACE-27 index might affect the postoperative survival, and therefore should be taken into accounts in the preoperative evaluation of the surgical indications.

Keywords

Non-small cell lung cancer Surgery Karnofsky Performance Status Adult Comorbidity Evaluation-27 Postoperative survival 

Notes

Acknowledgements

This study was funded by the National Hospital Organization (Tokyo, Japan). The authors declare no conflicts of interest in association with the present study. This manuscript was reviewed by all authors. The corresponding author had full access to the study data and takes full responsibility for the final decision to submit the manuscript. We thank the patients, all of the investigators who participated in the study, and the Data Center at the Kyushu Cancer Center. This manuscript was edited in English by Mr. Brian Quinn, the Official English Medical Editor of the Japan Surgical Society.

Funding

This work was supported by the National Hospital Organization (Tokyo, Japan).

Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.

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Copyright information

© The Japanese Association for Thoracic Surgery 2018

Authors and Affiliations

  • Tokujiro Yano
    • 1
  • Mototsugu Shimokawa
    • 2
  • Osamu Kawashima
    • 3
  • Mitsuhiro Takenoyama
    • 4
  • Yoshinori Yamashita
    • 5
  • Takeshi Fukami
    • 6
  • Tsuyoshi Ueno
    • 7
  • Eiji Yatsuyanagi
    • 8
  • Seiichi Fukuyama
    • 1
  • For the National Hospital Organization Network Collaborative Research—Thoracic Oncology Group
  1. 1.Department of General Thoracic SurgeryNational Hospital Organization Beppu Medical CenterBeppuJapan
  2. 2.Cancer Biostatistics Laboratory, Clinical Research InstituteNational Hospital Organization Kyushu Cancer CenterFukuokaJapan
  3. 3.Department of Chest SurgeryNational Hospital Organization Shibukawa Medical CenterShibukawaJapan
  4. 4.Department of Thoracic OncologyNational Hospital Organization Kyushu Cancer CenterFukuokaJapan
  5. 5.Department of Chest SurgeryNational Hospital Organization Kure Medical Center and Chugoku Cancer CenterKureJapan
  6. 6.Department of Thoracic SurgeryNational Hospital Organization Tokyo National HospitalTokyoJapan
  7. 7.Department of General Thoracic SurgeryNational Hospital Organization Shikoku Cancer CenterMatsuyamaJapan
  8. 8.Department of General Thoracic SurgeryNational Hospital Organization Obihiro HospitalObihiroJapan

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