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Multicenter prospective study of sublobar resection for c-stage I non-small cell lung cancer patients unable to undergo lobectomy (KLSG-0801): complete republication

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Abstract

Background

Local therapy for stage I non-small cell lung cancer (NSCLC) is divided into surgical and radiation treatment, and given to patients unable to tolerate a lobectomy. A prospective phase II study of cases that received stereotactic body radio therapy (SBRT) (JCOG0403) revealed an overall 3-year survival rate (3-YSR) of 76.0 %, 3-year relapse free survival rate (3-YRFS) of 69.0 %, and rate of morbidity of grade 3 or greater of 9 %. However, few prospective multicenter studies have reported regarding surgery for high-risk stage I NSCLC patients.

Methods

We investigated this issue in the setting of a prospective multicenter observational study. Thirty-two high-risk NSCLC patients (30 males, 2 females; median age 74 years, 61–85 years) were analyzed.

Results

Two (6.3 %) showed morbidity of grade 3 or greater, though there were no postoperative deaths. The margin local control rate was 97.0 % (surgical margin recurrence, 1) and local recurrence control rate was 75.0 % (ipsilateral thorax recurrence, 8), while the 3-YSR and 3-YRFS was 79.0 and 75.9 %, respectively.

Conclusion

A sublobar pulmonary resection for patients unable to tolerate a lobectomy with stage I NSCLC was shown to be safe and provided results comparable with those of SBRT.

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Authors and Affiliations

  1. General Thoracic Surgery, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan

    Nobumasa Takahashi & Eishin Hoshi

  2. Division of General Thoracic Surgery, Hoshigaoka Medical Center, Japan Community Healthcare Organization (JCHO), Hirakata, Osaka, 578-5811, Japan

    Noriyoshi Sawabata

  3. Division of Health Care, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Noriyoshi Sawabata

  4. Division of Surgery, Teikyo University School of Medicine, Itabashi, Tokyo, Japan

    Masafumi Kawamura

  5. General Thoracic Surgery, Keio University, Shinjyuku, Tokyo, Japan

    Takashi Ohtsuka

  6. General Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Bunkyou, Tokyo, Japan

    Hirotoshi Horio

  7. General Thoracic Surgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan

    Hirozou Sakaguchi

  8. General Thoracic Surgery, Saitama Medical University Saitama Medical Center, Kawagoe, Saitama, Japan

    Mitsuo Nakayama

  9. General Thoracic Surgery, Niigata Cancer Center Hospital, Niigata, Japan

    Katsuo Yoshiya

  10. General Thoracic Surgery, Dokkyo Medical University, Tokyo, Japan

    Masayuki Chida

Authors
  1. Nobumasa Takahashi
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  2. Noriyoshi Sawabata
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  3. Masafumi Kawamura
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  4. Takashi Ohtsuka
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  5. Hirotoshi Horio
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  6. Hirozou Sakaguchi
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  7. Mitsuo Nakayama
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  8. Katsuo Yoshiya
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  9. Masayuki Chida
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  10. Eishin Hoshi
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Corresponding author

Correspondence to Noriyoshi Sawabata.

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None of the authors have conflicts of interest to declare in regard to this study.

Additional information

For the Kanetsu Lung Cancer Study Group (KLSG).

This article is based on a study first reported in the Journal of the Japanese Association for Chest Surgery.

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Takahashi, N., Sawabata, N., Kawamura, M. et al. Multicenter prospective study of sublobar resection for c-stage I non-small cell lung cancer patients unable to undergo lobectomy (KLSG-0801): complete republication. Gen Thorac Cardiovasc Surg 64, 470–475 (2016). https://doi.org/10.1007/s11748-016-0662-z

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  • DOI: https://doi.org/10.1007/s11748-016-0662-z

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