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Impact of synchrotron radiation-based X-ray phase-contrast tomography on understanding various cardiovascular surgical pathologies

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Abstract

At SPring-8, synchrotron radiation-based X-ray phase-contrast tomography (PCXI) has been developed to measure the inner structures of biological soft tissue without destroying them. To resolve the three-dimensional (3D) morphology, we have applied PCXI to various cardiovascular tissue samples, including the thoracic aorta, ductus arteriosus, and cardiac conduction system. In the aortic walls, PCXI demonstrated differences in 3D structures of tunica media of aortic dissection. These findings correlated well with the irregularity of the structure of the media. In the surgically excised sample of coarctation of the aorta, PCXI showed 3D morphological changes in transition from the ductus arteriosus to the descending aorta. PCXI is also useful for examining abnormalities of the cardiac conduction system in congenital heart defects. Synchrotron radiation-based X-ray phase-contrast tomography has strong modality for analyzing 3D morphology and is useful for understanding the pathophysiology of various cardiovascular surgical pathologies.

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Acknowledgments

This study was approved by Japanese Red Cross Kobe Hospital Research Subjects Review Boards, Kobe Children Hospital Research Subjects Review Boards, and SPring-8 Proposal Review Committee (2012A1643, 2012B1785, 2013B1726, 2014A1733, 2014B1304, 2014B1306). A formalin-fixed fetus heart and coarctation of the aorta was provided by Drs. Yoshihiro Oshima and Makiko Yoshida at Kobe Children Hospital.

Conflict of interest

All the authors have declared no competing interest.

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Authors and Affiliations

  1. Division of Cardiovascular Surgery, Japanese Red Cross Kobe Hospital, 1-3-1 Wakihamakaigandori Chuo-ku, Kobe, 651-0073, Japan

    Takuro Tsukube

  2. Japan Synchrotron Radiation Research Institute (SPring-8), Sayo, Japan

    Naoto Yagi & Masato Hoshino

  3. Division of Pathology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan

    Yutaka Nakashima

  4. Division of Pathophysiological and Experimental Pathology, Kyushu University, Fukuoka, Japan

    Kazunori Nakagawa

  5. Division of Cardiovascular Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan

    Yutaka Okita

Authors
  1. Takuro Tsukube
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  2. Naoto Yagi
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  3. Masato Hoshino
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  4. Yutaka Nakashima
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  5. Kazunori Nakagawa
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  6. Yutaka Okita
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Corresponding author

Correspondence to Takuro Tsukube.

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Tsukube, T., Yagi, N., Hoshino, M. et al. Impact of synchrotron radiation-based X-ray phase-contrast tomography on understanding various cardiovascular surgical pathologies. Gen Thorac Cardiovasc Surg 63, 590–592 (2015). https://doi.org/10.1007/s11748-015-0565-4

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  • DOI: https://doi.org/10.1007/s11748-015-0565-4

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