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Collagen fleece failed to prevent intrapleural adhesions in a canine model: failure of murine models to translate into a large animal model

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Abstract

Intrapleural and anti-adhesive materials were investigated in murine models, but not in a large animal model before clinical application. Our results failed to show any anti-adhesion effect of collagen fleece and suggested the thoracic physiology in murine models would not translate into a large animal model.

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References

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All the authors have declared no competing interest.

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Authors and Affiliations

  1. Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

    Masatsugu Hamaji, Fumitsugu Kojima & Tatsuo Nakamura

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  1. Masatsugu Hamaji
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  2. Fumitsugu Kojima
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  3. Tatsuo Nakamura
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Correspondence to Masatsugu Hamaji.

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Hamaji, M., Kojima, F. & Nakamura, T. Collagen fleece failed to prevent intrapleural adhesions in a canine model: failure of murine models to translate into a large animal model. Gen Thorac Cardiovasc Surg 62, 202–203 (2014). https://doi.org/10.1007/s11748-013-0369-3

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  • DOI: https://doi.org/10.1007/s11748-013-0369-3

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