Skip to main content
Log in

Aortic valve replacement in an elderly patient with factor XI deficiency

  • Case Report
  • Published:
General Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Factor XI (FXI) deficiency is rare and associated with bleeding after surgical procedures. We report a case of an 80-year-old woman with severe aortic valve stenosis. FXI deficiency was diagnosed due to prolonged activated partial thromboplastin time. Aortic valve replacement was performed using a porcine bioprosthetic valve. Intra-operation bleeding was controlled by the transfusion of a fresh frozen plasma. The postoperative course was uneventful.

This is a preview of subscription content, log in via an institution to check access.

Access this article

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Fig. 1

Similar content being viewed by others

References

  1. Duga S, Salomon O. Factor XI deficiency. Semin Thromb Hemost. 2009;35:416–25.

    Article  PubMed  CAS  Google Scholar 

  2. Seligsohn U. Factor XI deficiency in humans. J Tromb Haemost. 2009;7:84–7.

    Article  CAS  Google Scholar 

  3. Bolton-Maggs PH. Factor XI deficiency and its management. Haemophilia. 2000;6:100–9.

    Article  PubMed  Google Scholar 

  4. The research of requirement coagulation factor products for coagulopathy in Japan 2010. Tokyo: Blood products research organization; 2010. p. 1–2.

  5. MacKinlay N, Taper J, Renisson F, Rickard K. Cardiac surgery and catheterization in patients with haemophilia. Haemophilia. 2000;6:84–8.

    Article  PubMed  CAS  Google Scholar 

  6. Vander Woude JC, Milam JD, Walker WE, Houchin DP, Weiland AP, Cooley DA. Cardiovascular surgery in patients with congenital plasma coagulopathies. Ann Thorac Surg. 1988;46:283–8.

    Article  PubMed  CAS  Google Scholar 

  7. Brunken R, Follette D, Wittig J. Coronary artery bypass in hereditary factor XI deficiency. Ann Thorac Surg. 1984;38:406–8.

    Article  PubMed  CAS  Google Scholar 

  8. Livnat T, Tamarin I, Mor Y, Winckler H, Horowitz Z, Korianski Y, et al. Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies. Thromb Haemost. 2009;102(3):487–92.

    PubMed  CAS  Google Scholar 

  9. Schulman S. Pharmacologic tools to reduce bleeding in surgery. Hematology. 2012;1:517–21.

    Google Scholar 

  10. Nowell J, Wilton E, Markus H, Jahangiri M. Antithrombotic therapy following bioprosthetic aortic valve replacement. Eur J Cardiothorac Surg. 2007;31:578–85.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Suguru Watanabe.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Watanabe, S., Minagawa, T., Kagatani, T. et al. Aortic valve replacement in an elderly patient with factor XI deficiency. Gen Thorac Cardiovasc Surg 62, 693–695 (2014). https://doi.org/10.1007/s11748-013-0271-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11748-013-0271-z

Keywords

Navigation