Skip to main content
SpringerLink
Log in

Aspergillus endocarditis in a native valve without prior cardiac surgery

  • Case Report
  • Published:
General Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

Abstract

Aspergillus native valve endocarditis continues to be a lethal disease, even when maximal therapeutic options are taken. We describe herein a patient with mitral valve endocarditis due to Aspergillus fumigatus following colon cancer and invasive pulmonary aspergillosis. Voriconazole was effective in controlling pulmonary and cerebral aspergillosis, despite the relative ineffectiveness for the vegetation. With the combination of aggressive medical and surgical therapy, the patient survived and remains without any evidence of infection 2 years later.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Gumbo T, Taege AJ, Mawhorter S, McHenry MC, Lytle BH, Cosgrove DM, et al. Aspergillus valve endocarditis in patients without prior cardiac surgery. Medicine (Baltimore). 2000;79:261–8.

    Article  CAS  Google Scholar 

  2. Pierrotti LC, Baddour LM. Fungal endocarditis, 1995–2000. Chest. 2005;122:302–10.

    Article  Google Scholar 

  3. Reis LJ, Barton TD, Pochettino A, Velazquez O, MaCarvey M, Milas B, et al. Successful treatment of Aspergillus prosthetic valve endocarditis with oral voriconazole. CID. 2005;41:752–3.

    Article  Google Scholar 

  4. Maderazo EG, Hickingbotham N, Cooper B, Murcia A. Aspergillus endocarditis: cure without surgical valve replacement. South Med J. 1990;83:351–2.

    Article  PubMed  CAS  Google Scholar 

  5. Martin MV, Yates J, Hitchcock CA. Comparison of voriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in Guinea pig. Antimicrob Agents Chemother. 1997;41:13–6.

    PubMed  CAS  Google Scholar 

  6. Herbrecht R, Denning DW, Patterson TF, Bennett JE, Grene RE, Oestmann JW, et al. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Eng J Med. 2002;347:408–15.

    Article  CAS  Google Scholar 

Download references

Conflict of interest

We do not have any financial or other interest in the manufacture or distributor of voriconazole.

Author information

Authors and Affiliations

  1. Department of Cardiovascular Surgery, Kousei General Hospital, Hiroshima, Japan

    Keiichiro Kuroki

  2. Department of Cardiovascular Surgery, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan

    Takashi Murakami

Authors
  1. Keiichiro Kuroki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takashi Murakami
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takashi Murakami.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuroki, K., Murakami, T. Aspergillus endocarditis in a native valve without prior cardiac surgery. Gen Thorac Cardiovasc Surg 60, 771–773 (2012). https://doi.org/10.1007/s11748-012-0076-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11748-012-0076-5

Keywords

Search

Navigation