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Efficacy of low-dose landiolol, an ultrashort-acting β-blocker, on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer

General Thoracic and Cardiovascular Surgery volume 59, pages 799–805 (2011)Cite this article

Abstract

Purpose

Postoperative atrial fibrillation is the most common complication encountered during the early postoperative period following a pulmonary resection procedure. Landiolol is a newly developed, ultrashortacting, β-adrenoceptor antagonist. The objective of the present study was to evaluate the efficacy and safety of low-dose landiolol for postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer.

Methods

Of 553 patients who underwent an elective pulmonary resection procedure for lung cancer at National Toneyama Hospital from January 2005 to December 2009, this analysis involved 30 consecutive patients who developed atrial fibrillation after surgery and needed treatment. These patients were divided into two groups: the landiolol group (n = 15) and the historical control group (treated with a combination of verapamil and digoxin, n = 15). Hemodynamic changes before and 30 min, 2 h, and 12 h after medication, the time required to restore sinus rhythm, and adverse events were evaluated.

Results

There were no significant differences between the two groups regarding blood pressure before and after medication. Heart rate was reduced immediately in both groups after medication and was significantly lower in the landiolol group than in the control group. The time to restore sinus rhythm was significantly shorter in the landiolol group than in the control group (8.1 ± 11.0 h vs. 23.0 ± 26.0 h, P < 0.05). In none of the subjects with the landiolol infusion was it discontinued because of side effects.

Conclusion

Low-dose landiolol can be effective quickly and used safely in patients who develop atrial fibrillation after pulmonary resection for lung cancer.

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Affiliations

  1. Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Osaka, Japan

    Takashi Nojiri, Hajime Maeda, Yukiyasu Takeuchi & Yasunobu Funakoshi

  2. Department of Internal Medicine, National Hospital Organization Toneyama Hospital, Osaka, Japan

    Ryoji Maekura

  3. Department of Cardiology, Osaka University Graduate School of Medicine, Osaka, Japan

    Kazuhiro Yamamoto

  4. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2 (L5) Yamadaoka, Suita, Osaka, 565-0871, Japan

    Takashi Nojiri & Meinoshin Okumura

Authors
  1. Takashi Nojiri
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  2. Kazuhiro Yamamoto
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  3. Hajime Maeda
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  4. Yukiyasu Takeuchi
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  5. Yasunobu Funakoshi
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  6. Ryoji Maekura
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  7. Meinoshin Okumura
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Correspondence to Takashi Nojiri.

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Nojiri, T., Yamamoto, K., Maeda, H. et al. Efficacy of low-dose landiolol, an ultrashort-acting β-blocker, on postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer. Gen Thorac Cardiovasc Surg 59, 799–805 (2011). https://doi.org/10.1007/s11748-011-0841-x

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  • DOI: https://doi.org/10.1007/s11748-011-0841-x

Key words

  • Arrhythmia
  • Lung cancer surgery
  • Perioperative care