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Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer

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Abstract

Purpose

The aim of this study was to determine if glucose transporter-1 (Glut1) expression correlates with 18F-FDG (18F-fluoro-2-deoxyglucose) uptake on positron emission tomography (PET) in lung cancer and to examine the similarities and differences between them.

Methods

A total of 34 patients with resected primary lung cancers were investigated in this study. There were 17 adenocarcinomas, 12 squamous cell carcinomas, and 5 cancers of other cell types. Immunohistochemical Glut1 intensity was categorized into three groups: negative, positive, and strongly positive. Glut1 frequency was defined by the proportion of positive cells among all cancer cells, and it was graded on a semiquantitative scale as 0–100% in 10% increments. The data are expressed as the mean ± SD.

Results

Maximum standardized uptake values (SUVmax) were 4.8 ± 6.3 in “negative” Glut1 intensity cases, 4.7 ± 3.1 in “positive” Glut1 intensity cases, and 11.2 ± 5.2 in “strongly positive” Glut1 intensity cases. Although SUVmax correlated significantly with tumor size (correlation coefficient 0.58, P = 0.00033), Glut1 frequency did not correlate significantly with tumor size (correlation coefficient 0.18, P = 0.301). Cell type and cell differentiation correlated significantly with Glut1 expression and 18F-FDG uptake.

Conclusion

Glut1 expression correlates significantly with 18F-FDG uptake. There are similarities in cell differentiation and cell type between Glut1 expression and 18F-FDG uptake. 18F-FDG uptake correlates significantly with tumor size, but Glut1 expression does not.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku Uchinada, Ishikawa, 920-0293, Japan

    Katsuo Usuda, Motoyasu Sagawa, Hirokazu Aikawa, Masakatsu Ueno, Makoto Tanaka, Yuichiro Machida, Xi-Tong Zhao & Tsutomu Sakuma

  2. Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University, Ishikawa, Japan

    Yoshimichi Ueda

  3. Department of Radiology, Asanogawa General Hospital, Ishikawa, Japan

    Koutaro Higashi

Authors
  1. Katsuo Usuda
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  2. Motoyasu Sagawa
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  3. Hirokazu Aikawa
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  4. Masakatsu Ueno
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  5. Makoto Tanaka
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  6. Yuichiro Machida
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  7. Xi-Tong Zhao
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  8. Yoshimichi Ueda
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  9. Koutaro Higashi
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  10. Tsutomu Sakuma
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Corresponding author

Correspondence to Katsuo Usuda.

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Usuda, K., Sagawa, M., Aikawa, H. et al. Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer. Gen Thorac Cardiovasc Surg 58, 405–410 (2010). https://doi.org/10.1007/s11748-010-0603-1

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  • DOI: https://doi.org/10.1007/s11748-010-0603-1

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