Abstract
We describe a rare case of a 79-year-old woman who developed herpes simplex virus pneumonia after mitral valve replacement. The patient showed persistent hypoxemia with bilateral glass-like shadows on chest radiography. Cytopathology examination of intratracheal secretions revealed herpes simplex virus infection. The patient, who improved gradually after acyclovir administration, was taken off the ventilator completely. Physicians should consider viral pulmonary infection to be a potential cause of unexplained hypoxemia that does not respond to conventional antibiotic treatment in critically ill, immunocompromised patients.
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Ramsey PG, Fife KH, Hackman RC, Meyers JD, Corey L. Herpes simplex virus pneumonia; clinical, virologic, and pathologic features in 20 patients. Ann Intern Med 1982;97:813–820.
Camps K, Jorens PG, Demey HE, Pattyn SR, Ieven M. Clinical significance of herpes simplex virus in the lower respiratory tract of critically ill patients. Eur J Clin Microbiol Infect Dis 2002;21:758–759.
Breyer RH, Andrews RI, Mills SA, Cordell AR, Ahl ET. Probable herpes simplex pneumonia after aortic valve replacement. JAMA 1983;249:1319–1322.
Arata K, Sakata R, Iguro Y, Toda R, Watanabe S, Eitsuru Y. Herpes simplex viral pneumonia after coronary artery bypass grafting. Jpn J Thorac Cardiovasc Surg 2003;51:158–159.
Shimokawa S, Watanabe S, Taira A, Eizuru Y. Herpes simplex virus pneumonia after cardiac surgery: report of a case. Surg Today 2001;31:814–816.
Whitney RJ, Roizman B. Herpes simplex virus infections. Lancet 2001;357:1513–1518.
Warren KG, Brown SM, Wroblewska Z, Gilden D, Koprowski H, Sudak-Sharpe J. Isolation of latent herpes simplex virus from the superior cervical and vagus ganglions of human beings. N Engl J Med 1978;298:1068–1069.
Bruynseels P, Jorens PG, Demey HE, Goossens H, Pattyn SR, Elseviers MM, et al. Herpes simplex virus in the respiratory tract of critical care patients: a prospective study. Lancet 2003;362:1536–1541.
Tajima K, Yamamoto F, Kawazoe K, Nakatani I, Sakai H, Abe T, et al. Cardiopulmonary bypass and cellular immunity: changes in lymphocyte subsets and natural killer cell activity. Ann Thorac Surg 1993;55:625–630.
Misoph M, Babin-Ebell J, Schwender S, Grossman R, Keller F, Elert O. Response of the cellular immune system to cardiopulmonary bypass in vivo. Thorac Cardiovasc Surg 1997;45:217–223.
Umans U, Golding RP, Duraku S, Manoliu RA. Herpes simplex virus 1 pneumonia: conventional chest radiograph pattern. Eur Radiol 2001;11:990–994.
Miyazato A, Kishimoto H, Tamaki K, Nakata K, Saito A. Herpes simplex virus bronchopneumonia in a non-immunocompromised individual. Intern Med 2001;40:836–840.
Vernon SE. Herpetic tracheobronchitis: immunohistologic demonstration of herpes simplex virus antigen. Hum Pathol 1982;13:683–686.
Geradts J, Warnock M, Yen TS. Use of the polymerase chain reaction in the diagnosis of unsuspected herpes simplex viral pneumonia: report of a case. Hum Pathol 1990;21:118–121.
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Yamaguchi, A., Matsumoto, S., Hagiwara, S. et al. Herpes simplex virus pneumonia following mitral valve replacement. Gen Thorac Cardiovasc Surg 58, 580–583 (2010). https://doi.org/10.1007/s11748-009-0537-7
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DOI: https://doi.org/10.1007/s11748-009-0537-7