Abstract
Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after lung transplantation, for which several risk factors including pretransplant seronegativity for Epstein-Barr virus are known. However, the impact of cytomegalovirus on PTLD remains to be determined. Here, we describe a case of Epstein-Barr virus-associated polymorphic PTLD that developed shortly after treatment for cytomegalovirus reactivation in a lung transplant recipient who was preoperatively seropositive for both cytomegalovirus and Epstein-Barr virus.
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Walker RC, Paya CV, Marshall WF, Stickler JG, Wiesner RH, Velosa JA, et al. Pretransplantation seronegative Epstein-Barr virus status is the primary risk factor for posttransplantation lymphoproliferative disorder in adult heart, lung, and other solid organ transplantations. J Heart Lung Transplant 1995;14:214–221.
Levine SM, Angel L, Anzueto A, Susanto I, Peters JI, Sako EY, et al. A low incidence of posttransplant lymphoproliferative disorder in 109 lung transplant recipients. Chest 1999;116:1273–1277.
Verschuuren EA, Stevens SJ, van Imhoff GW, Middeldorp JM, de Boer C, Koeter G, et al. Treatment of posttransplant lymphoproliferative disease with rituximab: the remission, the relapse, and the complication. Transplantation 2002;73:100–104.
Reams BD, McAdams HP, Howell DN, Steele MP, Davis RD, Palmer SM. Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. Chest 2003;124:1242–1249.
Lee P, Minai OA, Mehta AC, DeCamp MM, Murthy S. Pulmonary nodules in lung transplant recipients: etiology and outcome. Chest 2004;125:165–172.
Raj R, Frost AE. Lung retransplantation after posttransplantation lymphoproliferative disorder: a single-center experience and review of literature of PTLD in lung transplant recipients. J Heart Lung Transplant 2005;24:671–679.
Gascoigne AD, Shenton BK, White MD, Colquhoun IW, Dark JH, Corris PA. The value of plasma-soluble interleukin 2 receptor monitoring in lung transplantation. Transplantation 1993;56:1029–1031.
Paya CV, Fung JJ, Nalesnik MA, Kieff E, Green M, Gores G, et al. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. ASTS/ASTP EBV-PTLD Task Force and The Mayo Clinic Organized International Consensus Development Meeting. Transplantation 1999;68:1517–1525.
Gao SZ, Chaparro SV, Perlroth M, Montoya JG, Miller JL, DiMiceli S, et al. Post-transplantation lymphoproliferative disease in heart and heart-lung transplant recipients: 30-year experience at Stanford University. J Heart Lung Transplant 2003;22:505–514.
Walker RC, Marshall WF, Strickler JG, Wiesner RH, Velosa JA, Habermann TM, et al. Pretransplantation assessment of the risk of lymphoproliferative disorder. Clin Infect Dis 1995;20:1346–1353.
Manez R, Breinig MC, Linden P, Wilson J, Torre-Cisneros J, Kusne S, et al. Posttransplant lymphoproliferative disease in primary Epstein-Barr virus infection after liver transplantation: the role of cytomegalovirus disease. J Infect Dis 1997;176:1462–1467.
Rubin RH. Impact of cytomegalovirus infection on organ transplant recipients. Rev Infect Dis 1990;12(suppl 7):S754–S766.
Guppy AE, Rawlings E, Madrigal JA, Amlot PL, Barber LD. A quantitative assay for Epstein-Barr Virus-specifi c immunity shows interferon-gamma producing CD8+ T cells increase during immunosuppression reduction to treat posttransplant lymphoproliferative disease. Transplantation. 2007;84:1534–1539.
Gautam A, Morrissey PE, Brem AS, Fischer SA, Gohh RY, Yango AF, et al. Use of an immune function assay to monitor immunosuppression for treatment of post-transplant lymphoproliferative disorder. Pediatr Transplant 2006;10:613–616.
Chen F, Aoyama A, Okamoto T, Takahashi A, Satoda N, Fujinaga T, et al. Viral infection after lung transplantation. Kyobu Geka 2007;60:982–987.
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Aoyama, A., Omasa, M., Kondo, N. et al. Post-transplant lymphoproliferative disorder following cytomegalovirus reactivation in a lung recipient. Gen Thorac Cardiovasc Surg 58, 251–254 (2010). https://doi.org/10.1007/s11748-009-0526-x
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DOI: https://doi.org/10.1007/s11748-009-0526-x