Abstract
We report a case of thymic carcinoma with massive pericardial effusion in a 74-year-old man. This patient with dyspnea was referred to our hospital because of pericardial effusion detected by echocardiography. A chest computed tomography and magnetic resonance imaging showed an anterior mediastinal mass measuring 8.0 × 5.0 cm with massive pericardial effusion. The mass lesion was suggestive of thymic carcinoma or invasive thymoma. Initially, he underwent pericardial drainage. The collected fluid was serous and yellow, and cytological examination found no malignant cells. The tumor with partial pericardium was resected. Histopathological findings confirmed the lesion to be squamous cell carcinoma of the thymus. The etiology of a massive nonmalignant pericardial effusion associated with thymic carcinoma warrants further studies. The patient is alive without recurrence and without pericardial effusion at 3 years to date after the operation. Not all pericardial effusion associated with thymic cancer involves malignant effusion.
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References
Shimosato Y, Mukai K. Tumors of the mediastinum. In: Atlas of tumor pathology, 3rd series, fascicle 21. Washington, DC: Armed Forces Institute of Pathology; 1997. p. 42.
Suster S, Rosai J. Thymic carcinoma a clinicopathologic study of 60 cases. Cancer 1991;67:1025–1032.
Sperling B, Marschall J, Kennedy R, Pahwa P, Chibbar R. Thymoma: a review of the clinical and pathological findings in 65 cases. Can J Surg 2003;46:37–42.
Liu HC, Hsu WH, Chen YJ, Chan YJ, Wu YC, Huang BS, et al. Primary thymic carcinoma. Ann Thorac Surg 2002;73:1076–1081.
Pentz WH. Advanced heart block as a manifestation of a paraneoplastic syndrome from malignant thymoma. Chest 1990;116:1135–1136.
Woldow A, Kotler M, Goldstein S, Milcu M. Thymoma with pericardial tamponade. Clin Cardiol 1995;18:484–485.
Tseng YL, Wang ST, Wu MH, Lin MY, Lai WW, Cheng FF. Thymic carcinoma involvement of great vessels indicates poor prognosis. Ann Thorac Surg 2003;76:1041–1045.
Sadohara J, Fujimoto K, Müller NL, Kato S, Takamori S, Ohkuma K, et al. Thymic epithelial tumors: comparison of CT and MR imaging findings of low-risk thymomas, high-risk thymomas, and thymic carcinomas. Eur J Radiol 2006;60:70–79.
Hasegawa S, Ito H, Yoshinori T. A case of thymic cancer with pericardial tamponade as initial manifestation. Jpn J Cancer Chemother 2006;33:79–82.
Canedo MI, Otken L, Stefadouros MA. Echocardiographic features of cardiac compression by a thymoma simulating cardiac tamponade and obstruction of the superior vena cava. Br Heart J 1997;39:1038–1042.
Hsu CP, Chen CY, Chen CL. Thymic carcinoma: ten years’ experience in twenty patients. J Thorac Cardiovasc Surg 1994;107:615–620.
Loehrer PJ, Chen M, Kim K. Cisplatin, doxorubicin, and cyclophosphamide plus thoracic radiation therapy for limited-stage unresectable thymoma: an intergroup trial. J Clin Oncol 1997;15:3093–3099.
Tanaka H, Wakayama T, Nakade M. A case of advanced thymic carcinoma completely resected after chemotherapy. Jpn J Lung Cancer 2003;43:335–340.
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Nishi, T., Takamori, S., Muta, F. et al. Nonmalignant pericardial effusion associated with thymic cancer. Gen Thorac Cardiovasc Surg 58, 239–242 (2010). https://doi.org/10.1007/s11748-009-0506-1
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DOI: https://doi.org/10.1007/s11748-009-0506-1