Abstract
We report a case of suggestive synchronous triple squamous cell carcinoma (Sq) of the lung that occurred in the same lobe. Under a clinical diagnosis of triple lung cancer, lobectomy was performed. Pathological examination revealed two well-differentiated Sq and one poorly differentiated Sq. The analysis of epidermal growth factor receptor-tyrosine kinase mutations showed no mutation in each tumor. However, pathological findings and the positive rate of immunochemical reaction of p53 and Ki-67 were different in each tumor.
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Ferguson MK, DeMeester TR, DesLauriers J, Little AG, Piraux M, Golomb H. Diagnosis and management of synchronous lung cancers. J Thorac Cardiovasc Surg 1985;89:378–385.
Verhagen AF, Van de Wal HJ, Cox AL, Lacquet LK. Surgical treatment of multiple primary lung cancers. Thorac Cardiovasc Surg 1989;37:107–111.
Van Rens MTM, Zanen P, Brutel de la Riviere A, Elbers HRJ, Van Swieten HA, Van den Bosch JMM. Survival in synchronous versus single lung cancer: upstaging better reflects prognosis. Chest 2000;118:952–958.
Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg 1975;70:606–611.
Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, et al. AJCC cancer staging manual. 5th edn. Philadelphia: Lippincott-Raven; 1997.
Rosengart TK, Martini N, Ghosn P, Burt M. Multiple primary lung carcinomas: prognosis and treatment. Ann Thorac Surg 1991;52:773–778.
Bryant AS, Pereira SJ, Miller DL, Cerfolio RJ. Satellite pulmonary nodule in the lobe (T4N0) should not be staged as IIIB non-small cell lung cancer. Ann Thorac Surg 2006;82:1808–1814.
Van Rens MTM, Eijken EJE, Elbers JRJ, Lammers JWL, Tilanus MGJ, Slootweg PJ. P53 mutation analysis for definite diagnosis of multiple primary lung carcinoma. Cancer 2002;94:188–196.
Chang YL, Wu CT, Lin SC, Hsiao CF, Jou YS, Lee YC. Clonality and prognostic implications of p53 and epidermal growth factor receptor somatic aberrations in multiple primary lung cancers. Clin Cancer Res 2007;13:52–58.
Tsubouchi H, Sato N, Hiyama M, Kaimori M, Endo S, Sohara Y, et al. Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. Ann Thorac Surg 2006;82:1198–1204.
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Okita, R., Shimizu, K., Mimura, T. et al. Suggestive synchronous triple squamous cell carcinoma of the lung in the same lobe. Gen Thorac Cardiovasc Surg 58, 427–430 (2010). https://doi.org/10.1007/s11748-009-0476-3
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DOI: https://doi.org/10.1007/s11748-009-0476-3